ID   I3JMA7_ORENI            Unreviewed;       356 AA.
AC   I3JMA7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=LRRCT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010001.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000010001.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JMA7; -.
DR   STRING; 8128.ENSONIP00000010001; -.
DR   Ensembl; ENSONIT00000010009.2; ENSONIP00000010001.2; ENSONIG00000007939.2.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000155311; -.
DR   HOGENOM; CLU_000288_18_6_1; -.
DR   InParanoid; I3JMA7; -.
DR   OMA; QMSLNPW; -.
DR   TreeFam; TF351828; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR24373:SF390; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..356
FT                   /note="LRRCT domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025584168"
FT   TRANSMEM        309..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..61
FT                   /note="LRRNT"
FT                   /evidence="ECO:0000259|SMART:SM00013"
FT   DOMAIN          254..305
FT                   /note="LRRCT"
FT                   /evidence="ECO:0000259|SMART:SM00082"
SQ   SEQUENCE   356 AA;  40056 MW;  9D07A53F3F0B9FBA CRC64;
     MPGFGCNMLA AMFLLPLLLN AVLGFKLCPS TCLCYESSDL VDCRSRGLTR VPSSISHGTW
     LLDLSGNKVT EVHTRSFIGL WSLKILLMSN NSIHILHPQF LEKLDLSFNR LRWLPQDFSQ
     GLYSLQELRL SHNLLQHLDS KSLEDCGNLK KLDLSYNHIR GLDIKALSSL SRLSFLNLER
     NSLNVLKDGQ LNRQQTLEVL LLNYNNISKI EAESLAPLRR LSLLGLRGNQ LEHIRFKTFL
     KLQTTSTYLQ MSLNPWICDC ELQRIFGKIN HVRHLHVEDY KDIICHAPAQ LAGSLLASMD
     SQLCIAETAS VLVITITVML AVIGALVKAE RNRKNKQASR SVTFSPSSCA TLLTEC
//