ID   I3JMK7_ORENI            Unreviewed;       324 AA.
AC   I3JMK7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Leucine rich repeat containing 59 {ECO:0000313|Ensembl:ENSONIP00000010101.2};
GN   Name=lrrc59 {ECO:0000313|Ensembl:ENSONIP00000010101.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010101.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000010101.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005458266.1; XM_005458209.2.
DR   AlphaFoldDB; I3JMK7; -.
DR   STRING; 8128.ENSONIP00000010101; -.
DR   Ensembl; ENSONIT00000010110.2; ENSONIP00000010101.2; ENSONIG00000008020.2.
DR   GeneID; 100690486; -.
DR   CTD; 55379; -.
DR   eggNOG; KOG0473; Eukaryota.
DR   GeneTree; ENSGT00940000165932; -.
DR   HOGENOM; CLU_062247_1_0_1; -.
DR   InParanoid; I3JMK7; -.
DR   OMA; MKVVQAD; -.
DR   OrthoDB; 3109191at2759; -.
DR   TreeFam; TF316929; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        247..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          169..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  36665 MW;  B14D32ACB0498AAC CRC64;
     MSKNSKVLNL KDKISGNEVD LSLCNLTEVP VRELALFPKV TVVDLSCNNI TSLPPEFCNL
     THLVKVDLSK NQLTSLPDDL GNLVNLQHLD LYNNKLTNLP VSFSQLRSLK WLDLKDNPLE
     LGLAKAAGDC LDEKQCKQCA TKVLQHMRAI QEEVDRAREK RLLREKELER KREAKQRERE
     AREREARKRE KAEEKEKRRK EYNAQKAALA AQEQQKKKSE EKKKKNGQAA ADKKVAVESK
     PKPRRSVIGL IFKLLLLLLV GLAGVAAVCR LTDLQKEAFC LPINAAVDDG LSWAKEQQVV
     LRQLVQNLST AAKEFLESTQ TSKN
//