ID I3JMN6_ORENI Unreviewed; 742 AA.
AC I3JMN6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
GN Name=slc26a5 {ECO:0000313|Ensembl:ENSONIP00000010130.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010130.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010130.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_003458722.1; XM_003458674.4.
DR AlphaFoldDB; I3JMN6; -.
DR STRING; 8128.ENSONIP00000010130; -.
DR Ensembl; ENSONIT00000010139.2; ENSONIP00000010130.1; ENSONIG00000008044.2.
DR GeneID; 100690237; -.
DR KEGG; onl:100690237; -.
DR CTD; 375611; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; I3JMN6; -.
DR OrthoDB; 1067648at2759; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000005207; Linkage group LG17.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 104..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 137..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 188..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 300..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 385..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 449..465
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 480..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 535..726
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 742 AA; 81014 MW; FF5F3587D5D4D456 CRC64;
MDQQEVVAAA AREDEASQLI YRIERPVYNE TLIQTKLLKR KEDTTTNCQK LAEKFQCSSE
KAKSAALSFM PILSWLPSYP VRKYLFSDVV SGLSTGVVQL PQGLAYAMLA AVPPVYGLYS
SFYPVLLYTF FGTSRHISVG TFAVISLMIG GVAVREAPDS MYMNINATGS NASDAINVEL
RDKSRVQVAV MVTTLAGLIQ IVLGLLRFGF VAIYLTEPLV RGFTTAASMH VVISQLKYLL
GVETQRYSGF LSAIYSVKAV LSRITSTNIA TFLLGLGCII FLYVIKVLNE RFKKKLPIPI
PGEIIVVIVS TSISYGLSLS KEYKVHVVGN IPTGLRPPAA PNISLLPNLV TDSFAIAIVG
FSMDVSLAKI FALKHGYSVD GNQELIALGL CNFISSFFQT FAVTCSMSRS LVQESTGGKT
QIAGLLASLL VLVVVVAIGF VFEPLPQTAL AAIIMVNLIG MFKQFRDIPS LWRTSKIELA
IWVIAFIASV LLGLDYGLLV AVTFAILTVI YRTQSPKSSI LGHVANTGLY CDVDEYEEAA
EYEGIKIFHS NSSIYFANSD LYVNSLKEKT GLNPEHLQAA RKAQKKQKEK ANSNQSSPLK
ICAKYKDEAV THEVLPQGHV AVAEDQKNGQ FGDRHGDSAS EEAVFLEPFS TVHSIILDWT
SATFIDSVGA KAIRQVIKEY ATVDVRVVIA GCNRNLLAEL DTLKFFTKDL TTDILFPTVH
DAVLHCQHSN SHPSVAAVSD MT
//