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Database: UniProt
Entry: I3JMN6_ORENI
LinkDB: I3JMN6_ORENI
Original site: I3JMN6_ORENI 
ID   I3JMN6_ORENI            Unreviewed;       742 AA.
AC   I3JMN6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE   AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
GN   Name=slc26a5 {ECO:0000313|Ensembl:ENSONIP00000010130.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010130.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000010130.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   RefSeq; XP_003458722.1; XM_003458674.4.
DR   AlphaFoldDB; I3JMN6; -.
DR   STRING; 8128.ENSONIP00000010130; -.
DR   Ensembl; ENSONIT00000010139.2; ENSONIP00000010130.1; ENSONIG00000008044.2.
DR   GeneID; 100690237; -.
DR   KEGG; onl:100690237; -.
DR   CTD; 375611; -.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; I3JMN6; -.
DR   OrthoDB; 1067648at2759; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000005207; Linkage group LG17.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR   GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        104..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        137..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        188..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        269..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        300..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        354..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        385..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        449..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        480..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          535..726
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   742 AA;  81014 MW;  FF5F3587D5D4D456 CRC64;
     MDQQEVVAAA AREDEASQLI YRIERPVYNE TLIQTKLLKR KEDTTTNCQK LAEKFQCSSE
     KAKSAALSFM PILSWLPSYP VRKYLFSDVV SGLSTGVVQL PQGLAYAMLA AVPPVYGLYS
     SFYPVLLYTF FGTSRHISVG TFAVISLMIG GVAVREAPDS MYMNINATGS NASDAINVEL
     RDKSRVQVAV MVTTLAGLIQ IVLGLLRFGF VAIYLTEPLV RGFTTAASMH VVISQLKYLL
     GVETQRYSGF LSAIYSVKAV LSRITSTNIA TFLLGLGCII FLYVIKVLNE RFKKKLPIPI
     PGEIIVVIVS TSISYGLSLS KEYKVHVVGN IPTGLRPPAA PNISLLPNLV TDSFAIAIVG
     FSMDVSLAKI FALKHGYSVD GNQELIALGL CNFISSFFQT FAVTCSMSRS LVQESTGGKT
     QIAGLLASLL VLVVVVAIGF VFEPLPQTAL AAIIMVNLIG MFKQFRDIPS LWRTSKIELA
     IWVIAFIASV LLGLDYGLLV AVTFAILTVI YRTQSPKSSI LGHVANTGLY CDVDEYEEAA
     EYEGIKIFHS NSSIYFANSD LYVNSLKEKT GLNPEHLQAA RKAQKKQKEK ANSNQSSPLK
     ICAKYKDEAV THEVLPQGHV AVAEDQKNGQ FGDRHGDSAS EEAVFLEPFS TVHSIILDWT
     SATFIDSVGA KAIRQVIKEY ATVDVRVVIA GCNRNLLAEL DTLKFFTKDL TTDILFPTVH
     DAVLHCQHSN SHPSVAAVSD MT
//
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