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Database: UniProt
Entry: I3JMS7_ORENI
LinkDB: I3JMS7_ORENI
Original site: I3JMS7_ORENI 
ID   I3JMS7_ORENI            Unreviewed;       499 AA.
AC   I3JMS7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE            EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
GN   Name=farsa {ECO:0000313|Ensembl:ENSONIP00000010171.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010171.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000010171.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00006703}.
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DR   AlphaFoldDB; I3JMS7; -.
DR   STRING; 8128.ENSONIP00000010171; -.
DR   Ensembl; ENSONIT00000010180.2; ENSONIP00000010171.2; ENSONIG00000008075.2.
DR   eggNOG; KOG2784; Eukaryota.
DR   GeneTree; ENSGT00390000006387; -.
DR   HOGENOM; CLU_025086_2_2_1; -.
DR   InParanoid; I3JMS7; -.
DR   OMA; QIEGWVM; -.
DR   TreeFam; TF300647; -.
DR   Proteomes; UP000005207; Linkage group LG4.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00496; PheRS_alpha_core; 1.
DR   Gene3D; 1.10.10.2320; -; 1.
DR   Gene3D; 1.10.10.2330; -; 1.
DR   Gene3D; 3.30.1370.240; -; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR   InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR   InterPro; IPR040724; PheRS_DBD1.
DR   InterPro; IPR040586; PheRS_DBD2.
DR   InterPro; IPR040725; PheRS_DBD3.
DR   NCBIfam; TIGR00468; pheS; 1.
DR   PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR   PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF18552; PheRS_DBD1; 1.
DR   Pfam; PF18554; PheRS_DBD2; 1.
DR   Pfam; PF18553; PheRS_DBD3; 1.
DR   Pfam; PF01409; tRNA-synt_2d; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          229..490
FT                   /note="Aminoacyl-transfer RNA synthetases class-II family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50862"
SQ   SEQUENCE   499 AA;  56900 MW;  B82232D5E9E6F115 CRC64;
     MADTGVLETL LQRVEKVDDG VDSLDVATSL GVDHQVIVGA VKSLQALGDV ISAELRSSKH
     WELTEEGTEI AEQGSHESRV FSCIPLEGLA QSELMKLPFG KIGFSKAMSN KWIRVDKAHE
     GGPRIFRTVE SIEDQVREKL FLVQKGNSTQ LEEKEKNELK KRKLLSEVTV KSYWITKGNS
     FSTTITKQET ELTPEMIASG NWKEKKFKPY NFEAMGVAPD CGHLHPLMKV RTQFRQIFLE
     MGFTEMPTNN FIESSFWNFD SLFQPQQHPA RDQHDTFFLS DPAHAHQFPQ DYLERVKKVH
     SEGGYGSQGY KYDWKIEEAQ KNILRTHTTA VSARMLYKLA QQKFTPVKYF SIDRVFRNET
     LDATHLAEFH QIEGVVADYG LTLGDLMGVL HQFFTKLGIT KLRFKPAYNP YTEPSMEVFS
     YHEGLKKWVE VGNSGVFRPE MLLPMGLPEG VSVIAWGLSL ERPTMIKYGI NNIRELVGHK
     VNLQMVYDSP ICRNPPTHF
//
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