ID I3JNP3_ORENI Unreviewed; 459 AA.
AC I3JNP3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=RNA binding protein fox-1 homolog 2 {ECO:0000313|Ensembl:ENSONIP00000010487.2};
GN Name=LOC100692969 {ECO:0000313|Ensembl:ENSONIP00000010487.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010487.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010487.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3JNP3; -.
DR STRING; 8128.ENSONIP00000061367; -.
DR Ensembl; ENSONIT00000010496.2; ENSONIP00000010487.2; ENSONIG00000008341.2.
DR eggNOG; KOG0125; Eukaryota.
DR GeneTree; ENSGT00940000157534; -.
DR HOGENOM; CLU_048440_0_1_1; -.
DR TreeFam; TF315942; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12407; RRM_FOX1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR034237; FOX1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR047131; RBFOX1-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15597; ATAXIN 2-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15597:SF49; RNA BINDING PROTEIN FOX-1 HOMOLOG; 1.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 207..283
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 86..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 47062 MW; E73340B1EC3D575C CRC64;
MLMSTDVASI MLPVSRGIMD RERDIDTAAG PHANAAGGPA VVRGMKRGDP EPDAQTAAAL
TDLSGAECKR PRIDGTGSVV GDIGQNNEPL NPGFHGYQPH SQGSQDSTGG QEGLVAPPFT
AFPPPPPPQN GLPGTEFGPG AMFGAGGQGT AEVGAGANGA PTSTNNNSSN VKTEETSQGE
AGVQCGAGGT GAGGSAGDST EAKGTPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF
NERGSKGFGF VTFENSADAE KAREKLHGTL VEGRKIEVNN ATARVMTNKK MVSPYPNGEA
LSTLPYAGWK LSPVVGAMYG PEIYAVPGFP YPTAAAAATT AAAAFRGAHL RGRGRPVYSA
VRAAVPQPAI PAYPGLVFQD SVLSPRLPQG GYPAAAAAAA AYRYAQPAAV TGATAAAAAY
SDSYGRVYTT DPYHALAPAA AAYGVGAMCF GSTEGFWIR
//
