ID I3JP89_ORENI Unreviewed; 373 AA.
AC I3JP89;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Muscleblind-like protein 2a {ECO:0000313|Ensembl:ENSONIP00000010683.2};
GN Name=MBNL2 {ECO:0000313|Ensembl:ENSONIP00000010683.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010683.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000010683.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the muscleblind family.
CC {ECO:0000256|ARBA:ARBA00038226}.
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DR RefSeq; XP_019208683.1; XM_019353138.1.
DR AlphaFoldDB; I3JP89; -.
DR STRING; 8128.ENSONIP00000059672; -.
DR Ensembl; ENSONIT00000010692.2; ENSONIP00000010683.2; ENSONIG00000008499.2.
DR eggNOG; KOG2494; Eukaryota.
DR GeneTree; ENSGT00950000182897; -.
DR HOGENOM; CLU_053536_0_0_1; -.
DR TreeFam; TF321931; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1370.210; -; 2.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12675; MUSCLEBLIND-LIKE PROTEIN; 1.
DR PANTHER; PTHR12675:SF4; MUSCLEBLIND-LIKE PROTEIN 2; 1.
DR Pfam; PF14608; zf-CCCH_2; 3.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR PROSITE; PS50103; ZF_C3H1; 4.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 13..41
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 47..73
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 183..211
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 219..245
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 13..41
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 47..73
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 183..211
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 219..245
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 160..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 40160 MW; 58F640F08545EB03 CRC64;
MALNISSARD TKWLTLEVCR QFQRGNCSRT DEECKFAHPS KSCQIENGRV IACFDSLKGR
CSRENCKYLH PPSHLKTQLE INGRNNLIQQ KTAAAVLAQQ MQLMIPGPSL QPVPTFTQGL
GTNAGLGYGS YMTPLSHGMS LIPSDILSST PVLVPGSSPV SVQCSSSSSS SSSSSPSQKL
QRSDKLEVCR EFQRGSCARG ETDCRFAHPS DSPMIDTMDN TVTVCMDYIK SRCSREKCKY
FHPPAHLQAK IKSSQQQVNQ TAVAAQAAAA AVAFPHSVLQ PLPKRPVLEK CSWASSLLSP
SLLHYQQALA SSQTLQQPTA AFYPTGSVLC MTPANGIVPM MYSATPATVS AATTPATSVP
YAATAPTNQI ILK
//
