ID   I3JPC8_ORENI            Unreviewed;       608 AA.
AC   I3JPC8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=Endoplasmin {ECO:0000256|ARBA:ARBA00039709};
DE   AltName: Full=Heat shock protein 90 kDa beta member 1 {ECO:0000256|ARBA:ARBA00042650};
GN   Name=hsp90b1 {ECO:0000313|Ensembl:ENSONIP00000010722.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010722.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000010722.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Melanosome {ECO:0000256|ARBA:ARBA00004223}.
CC       Sarcoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004564}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000256|ARBA:ARBA00008239}.
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DR   AlphaFoldDB; I3JPC8; -.
DR   STRING; 8128.ENSONIP00000033403; -.
DR   Ensembl; ENSONIT00000010731.2; ENSONIP00000010722.2; ENSONIG00000008526.2.
DR   eggNOG; KOG0020; Eukaryota.
DR   GeneTree; ENSGT01020000230401; -.
DR   HOGENOM; CLU_006684_1_3_1; -.
DR   TreeFam; TF105969; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 3.30.230.80; -; 1.
DR   Gene3D; 3.40.50.11260; -; 1.
DR   Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   PANTHER; PTHR11528:SF97; ENDOPLASMIN; 1.
DR   PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   REGION          113..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..141
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  70087 MW;  00243E6EBC29C1CF CRC64;
     MTEMQEEGQS TSELIGQFGV GFYSAFLVAD KVIVTSKHNN DTQHIWESDS NQFSVIEDPR
     GDTLGRGTTI TLVLKEEASD YLELETIKNL VKKYSQFINF PIYVWASKTE TVEEPIEEDA
     EAAEEPEKEA SEDEAEVEEE EGEDKDKPKT KKVEKTVWDW ELMNDIKPIW QRPAKEVEED
     EYKAFYKTFS KDNDDPMAHI HFTAEGEVTF KSILFVPTSA PRGLFDEYGS KKNDYIKLFV
     RRVFITDDFN DMMPKYLNFI KGVVDSDDLP LNVSRETLQQ HKLLKVIRKK LVRKTLDMIK
     KIAEEQYNDK FWKEFGTNIK LGVIEDHSNR TRLAKLLRFQ TSNSETDLSS LEQYVERMKE
     KQDKIYFMAG TSRKEAESSP FVERLLKKGY EVIYLTEPVD EYCIQALPEF DGKRFQNVAK
     EGVKFDESEK AKEKREALEK EFEPLTTWLK DKALKDKIEK AVLSQRLTNS PCALVASQYG
     WSGNMERIMK AQAYQTGKDI STNYYASQKK TLELNPKHPL VKQLLNRVNA DAEDQTASDL
     AVVLFETATL RSGYQLVDTK AYGDRIERML RLSLNVPLDE QAILVSVSEL MVPLPSVTFF
     EFSPVSAF
//