ID I3JPH6_ORENI Unreviewed; 611 AA.
AC I3JPH6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 1 {ECO:0000313|Ensembl:ENSONIP00000010770.1};
GN Name=nr2c1 {ECO:0000313|Ensembl:ENSONIP00000010770.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010770.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010770.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR RefSeq; XP_005450993.1; XM_005450936.3.
DR RefSeq; XP_005450994.1; XM_005450937.3.
DR RefSeq; XP_019217278.1; XM_019361733.1.
DR RefSeq; XP_019217279.1; XM_019361734.1.
DR AlphaFoldDB; I3JPH6; -.
DR STRING; 8128.ENSONIP00000010770; -.
DR Ensembl; ENSONIT00000010779.2; ENSONIP00000010770.1; ENSONIG00000008566.2.
DR GeneID; 100703800; -.
DR KEGG; onl:100703800; -.
DR CTD; 7181; -.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000158165; -.
DR HOGENOM; CLU_007368_16_2_1; -.
DR InParanoid; I3JPH6; -.
DR OMA; QDQGPNK; -.
DR OrthoDB; 5400963at2759; -.
DR TreeFam; TF316650; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF49; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 117..192
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 356..599
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 296..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 67213 MW; 49524BEA58974FBF CRC64;
MDGQTQRFQL VSADNNMALG HRIQIVTDQQ TGQKIQIVTA LEPSSPGKQQ FILANADYSP
GGKVILAKQE GSPNKVILTT PDGSGVNQLL FASPELTGQQ IQFVTESSDQ SIVKPVVEYC
VVCGDKASGR HYGAVSCEGC KGFFKRSIRK NLVYTCRGSG ECAINKLHRN RCQYCRLQRC
IALGMKQDSV QCERKPVEVT AREKSVNCAA STEKIYIRKN LCSPLAATPT FASDKETARS
ASLLESSMLL NIQQPFSKLE NTILIPASPE KQEDPSQGDL GTLANVVTSL AHLNKSREAS
DSGNDLMGAE TLSNGDSSMT DIQGDEQTAS DISRAFDTLA KVLHPGDGSA GESLEATMQL
MSGDQSGPVV ELEGPLLSDS HIPFKLMMPL PVPEYLNVNY ICESASRLLF LSMHWARSIP
AFQTLGGQDN DINLMKFCWN ELFALGLAQC SNVMNVGTIL SAIINHLQTS LQEEKLSPER
GKIVMEHIWR MQEFCNSMSK LSPDSYEYAY LKAIVLFSPD HPGIDNIPQI ERFQEKAYME
LQDYVTRTYP EDSYRLSKLL LRLPALRLIS AAVTEELFFA GLIGNVQIDS IIPYILKMES
TDYNSQAVSA V
//
