ID I3JQ86_ORENI Unreviewed; 647 AA.
AC I3JQ86;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 {ECO:0000313|Ensembl:ENSONIP00000011030.2};
GN Name=appl2 {ECO:0000313|Ensembl:ENSONIP00000011030.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011030.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011030.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3JQ86; -.
DR STRING; 8128.ENSONIP00000068145; -.
DR Ensembl; ENSONIT00000011039.2; ENSONIP00000011030.2; ENSONIG00000008773.2.
DR GeneTree; ENSGT00940000158319; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd13247; BAR-PH_APPL; 1.
DR CDD; cd13158; PTB_APPL; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047181; DP13A/B.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047236; PH_DP13A/B.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR047237; PTB_APPL.
DR PANTHER; PTHR46415; ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2; 1.
DR PANTHER; PTHR46415:SF1; DCC-INTERACTING PROTEIN 13-BETA; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..647
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025662679"
FT DOMAIN 264..362
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 473..531
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 439..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 72642 MW; 5166CCD6C629DCF1 CRC64;
GKLLDKVFLI ISLCTRSLLS VFEEDVGMLT DYTNQLLQSM QRVFGAQSEM GLATEQLSKQ
LLEYEKKNFA LGKGDEEVIT TLQNFAKTVG ELNALHSELA NQMADSMVFP LIQFREKDLT
VFLLFCAEHE AAMVKYSRLP KKKENEKLKA DLVKEVAYTR RKQHQASLQY YCALNALQYR
KRVAMLEPML GYTHAQISFF KKGFELVSKK MDSFLASVSN MTQSIQAQLD SEAEAMRVSH
RELLSVEDTV YMPDKDTEPV NRTLIQKAGY LNIRNKTGLV TTAWDRLYFF TQGGNLMCQP
RGAVAGGMVL DLDNSSVMAV DCEDRRYCFQ ITSPSGKTSM ILQAESKKEY EEWICTVNNI
SRQIYLTDNP EAVAIRLNQT AIQAVTPITS FEKRQDGSPN PDRSGMYFGN KTGVAPEPED
LIAPGTPIQF DIMLPASEFQ DQNRTGGRRT NPFGETEDDC STETDDSLLQ QVFAVRFLGS
MAVRCGDNQE VIYEAMRQVL AARAIHNIFR TTEAHLMVTS SSLRLIDPQT QVTRLSFQLG
EVCQFAAHQE NGRLMGFVVE ARDWSNGDEE GEPSFSAFVF ESNTEGEKIC YTINLAKEIT
EAKKDPEALA QLMKNMPLTN DGKFLLLEPE TGDTTEGAGQ EDLESEA
//
