ID I3JQL3_ORENI Unreviewed; 533 AA.
AC I3JQL3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011157.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011157.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; I3JQL3; -.
DR STRING; 8128.ENSONIP00000011157; -.
DR Ensembl; ENSONIT00000011166.2; ENSONIP00000011157.2; ENSONIG00000008874.2.
DR eggNOG; KOG4385; Eukaryota.
DR GeneTree; ENSGT00940000155480; -.
DR HOGENOM; CLU_019502_3_1_1; -.
DR InParanoid; I3JQL3; -.
DR OMA; MQQIWKE; -.
DR TreeFam; TF326978; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20065; FH_FOXP2; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF4; FORKHEAD BOX P, ISOFORM C; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 338..411
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 338..411
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 126..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 59316 MW; AB0C3C3E8336AEB6 CRC64;
MVISPDLKLC FSKHKSPESI SKHLPALTLN GLTGLTVVRQ KRVRAAFTTS VEMLSFPVLQ
LSSPQLVFQQ LIQLQQQQQQ QLLRAHRPAL SSPALSPACL SPAEMQQVWK ELTLAMTEDK
TAIKANRESS TGKIMSAKVP GRQADDQQSA CPHRAESTVK GDHAAKHALF GHGVCNWPGC
ESVCENFSQF IKHISSEHSL DDRSTAQCRV QMQVVQQLEL QLCKERERLQ AMMAHLHLPS
LEAQSLSAPA QSPQSDAAAD PCGLQLTSVN SLPSLNSSDP AQVSPRPLDP VGTPSQRGEK
EFPSHTSGVG PMRRRNHPLV YSLSSENEYE LYKNTDLRPP FTYATLIRQA IMEASDMQLT
LNDIYNWFTR TFAYFRRNAA TWKNAVRHNL SLHKCFVRVE NVKGAVWTVD EVEYQRRRSQ
KITGNPSLMK SISSSAGFGT LMNSGLQTAL AEASLPGLKK DNVRGNSKSQ IQKSSMADSH
RNQNFSPRVQ PPLFLEDKEL KMNDQGCLIQ TVKPVSLQPD MSENDEGHLF DLE
//
