ID   I3JQL5_ORENI            Unreviewed;       453 AA.
AC   I3JQL5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Putative sodium-coupled neutral amino acid transporter 11 {ECO:0000256|ARBA:ARBA00040814};
DE   AltName: Full=Solute carrier family 38 member 11 {ECO:0000256|ARBA:ARBA00041723};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011159.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000011159.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC       {ECO:0000256|ARBA:ARBA00037101}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000256|ARBA:ARBA00008066}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; I3JQL5; -.
DR   STRING; 8128.ENSONIP00000048564; -.
DR   Ensembl; ENSONIT00000011168.2; ENSONIP00000011159.2; ENSONIG00000008876.2.
DR   eggNOG; KOG1305; Eukaryota.
DR   GeneTree; ENSGT00940000157782; -.
DR   HOGENOM; CLU_009020_4_2_1; -.
DR   TreeFam; TF328787; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR   PANTHER; PTHR22950:SF458; SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED; 1.
DR   Pfam; PF01490; Aa_trans; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        249..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          25..409
FT                   /note="Amino acid transporter transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01490"
SQ   SEQUENCE   453 AA;  49363 MW;  55BC7984BEDCD529 CRC64;
     MAQQLNSEEG TTLIPLQKDA RKSRNSMISA SFNFINSIIG SGIIGLPYAL NQAGLPFGLL
     LLIVVGFITD YSIILLIKGG NLSGTNSYQS LVHSTFGFPG FVILSGLQFL YPFIAMISYN
     ITIGDTLTKV FQRIPGVGPD HILAERHFVI ILSTVVFTLP LSLYRNIERL GKVSFLSMVL
     TVIILIIVII RAATFGPQIL PTDDAWAFAK WNAIQAVGVM SFAFICHHNS FLIYGSLEQP
     TLANWSQVTH ISVGSALIIS AGFAVAGYTT FTGYTQGDIF ENYCRNDNLA TFGRFCFGIS
     IITTFPLECF VTREVVSNVI CSRDLSKTEH AAITMLIVAV CTSISLAYDC LGVVLELNGA
     LSATPLIFII PSACFLKLSS GRWFDGENLI PAVLIIIGLF IMITGLIMTG IYPQGCSHGV
     EMFYCADANA SSTVPPLLLY VVMSSRKFTR KRK
//