ID   I3JQW9_ORENI            Unreviewed;       732 AA.
AC   I3JQW9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011263.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000011263.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JQW9; -.
DR   Ensembl; ENSONIT00000011272.2; ENSONIP00000011263.2; ENSONIG00000039141.1.
DR   eggNOG; ENOG502SBIG; Eukaryota.
DR   GeneTree; ENSGT01100000263487; -.
DR   TreeFam; TF352120; -.
DR   Proteomes; UP000005207; Linkage group LG3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 2.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          160..294
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   732 AA;  83219 MW;  B3A5B694FBA0B14F CRC64;
     MLLEDNIITF VKNELKKIQK ALNPNKPQCL EFQREDDEQR SSREAFVKIT VDFLRRMKQQ
     ELADRLQSKL PAAVCHRNLK SALKKKFQCV FEGIAKAGNP ALLNEIYTEL YITEGGTAEV
     NDEHEVRQIE TASRKPDRPE TTIRHEDIFK ALPGRDEPIR TVLTKGVAGI GKTVLTQKYT
     LDWAEDKANQ DIQFIFPFTF RELNVLKEEK FSLVELVHHF FTETKEAGIC SFEDFQVVFI
     FDGLDECRLP LDFHKTTILT DPRKSTSVDV LLINLIRGKL LPSAHLWITT RPAAANQIPP
     DCVGMLTEVR GFTDPQKEEY FRKRFRDEEQ ASRIISHIKT SRSLHIMCHI PVFCWITAAV
     LEDVLETREG GQLPKTLTEM YIHFLVVQAK VKKIKYDGGA ETDPHWSPES RKMIESLGKL
     AFVQLQKGNL IFYESDLTEC GIDIRAASVY SGVFTQIFKE ERGLYQDKVF CFIHLSVQEF
     LAALHVHLTF INSRLNLLEE QQTTSKIFKR RNSLERQILF QSAVNKALQS PNGHLDLFLR
     FLLGLSLQTN QTLLRGLLTQ TGSSSQTNQE TVQYIKKKLS ENLSAEKSIN LFHCLNELND
     RSLVEEIQQT LRSGSLSTDK LSPAQWSALV FILLSSEKDL DVFDLKKYSA SEEALLRLLP
     VVKASNKALL SGCNLSDRSC EALSSVLSSQ SSGLTELDLG NNNLQDSGVK FLSAGMKSQY
     CKLETLRSDR AI
//