ID   I3JR61_ORENI            Unreviewed;       611 AA.
AC   I3JR61;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Insulin like growth factor 2 mRNA binding protein 2 {ECO:0000313|Ensembl:ENSONIP00000011355.2};
GN   Name=igf2bp2 {ECO:0000313|Ensembl:ENSONIP00000011355.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011355.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000011355.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC       {ECO:0000256|ARBA:ARBA00009094}.
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DR   RefSeq; XP_003447396.1; XM_003447348.4.
DR   AlphaFoldDB; I3JR61; -.
DR   SMR; I3JR61; -.
DR   STRING; 8128.ENSONIP00000011355; -.
DR   Ensembl; ENSONIT00000011364.2; ENSONIP00000011355.2; ENSONIG00000009029.2.
DR   GeneID; 100710585; -.
DR   KEGG; onl:100710585; -.
DR   CTD; 100136839; -.
DR   eggNOG; KOG2193; Eukaryota.
DR   GeneTree; ENSGT00940000154913; -.
DR   HOGENOM; CLU_020744_1_0_1; -.
DR   InParanoid; I3JR61; -.
DR   OMA; SYETQEQ; -.
DR   OrthoDB; 3035007at2759; -.
DR   TreeFam; TF320229; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd22497; KH-I_IGF2BP2_rpt3; 1.
DR   CDD; cd22500; KH-I_IGF2BP2_rpt4; 1.
DR   CDD; cd12629; RRM2_IGF2BP2; 1.
DR   Gene3D; 3.30.310.210; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR10288:SF93; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2; 1.
DR   PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR   Pfam; PF00013; KH_1; 4.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00322; KH; 4.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 4.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          2..75
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          81..156
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          158..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  66601 MW;  A1E9482D9C971906 CRC64;
     MNKLYVGNLS PSVTVEDLKQ LFGERKLPVA DQVLLKSGYA FVDFPDQNSA IKAIETLSGK
     VELHGKVIEV DYSVPKKLRS RKIQIRNIPP HLQWEVLDGL LAQYGTVENV EQVNTDTETA
     VVNVTYATKE EAKVAIEKLT GHQFDDYSFK VSYIMDTDAA PPVQAPRTRR GGRSSRDQGS
     SQPGPSGGYG SPRPRQHDFP LRMLVPTQFV GAIIGKEGNT IKDVTKQTQS KVDIHRKENA
     GAAEKPITIH STPEGCSAAC RMILDIMQKE ANETKTTEDI PLKILAHNSL VGRLIGKEGR
     NLKKIEEDTG TKITISSLQD LTIYNPERTI TVKGSIDACC KAEVEITKKL REAYENDIAA
     INQQANLIPG LNLNALGIFS SGLPVLPPAA GPRSAVPAVA PAGYNPFLSH SSHLSGLYGV
     PPASAIPHQH SQQAPEQEVV YLFIPTQAVG ALIGKKGQHI KQLAHFAGAS IKIAPAESPD
     VTERMVIITG TPEAQFKAQG RIFGKLKEEN FFSAKEEVKL ETHIKVPSSA AGRVIGKGGK
     TVNELQNLTS AEVIVPRDQT PDENDEVFVK ISGHFFASQT AQRKIREIIQ QVKQQEQKHQ
     QGAAVSPHHS K
//