ID I3JRV8_ORENI Unreviewed; 1068 AA.
AC I3JRV8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Integrin alpha-3 {ECO:0000313|Ensembl:ENSONIP00000011603.2};
GN Name=LOC100705213 {ECO:0000313|Ensembl:ENSONIP00000011603.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011603.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011603.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_019213052.1; XM_019357507.1.
DR AlphaFoldDB; I3JRV8; -.
DR STRING; 8128.ENSONIP00000011603; -.
DR Ensembl; ENSONIT00000011612.2; ENSONIP00000011603.2; ENSONIG00000009224.2.
DR GeneID; 100705213; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000157746; -.
DR HOGENOM; CLU_004111_1_0_1; -.
DR InParanoid; I3JRV8; -.
DR OMA; YMNAGGR; -.
DR OrthoDB; 3816176at2759; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1068
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5025715183"
FT TRANSMEM 983..1005
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 20..87
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 282..342
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 343..398
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 402..463
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 448..594
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 596..748
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 757..970
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT COILED 852..879
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1068 AA; 118278 MW; 58F5888D15665DF8 CRC64;
MATGVCMLLV VCISMCAAFN LDTSFPLLKM GERGSLFGFS VALHQDLKTE SYLLLVGAPR
EKAEPNVPAN HTGGVYTCPI SANQSDCRRM KLIDPTQIYA DELVEDMWLG VSVASQGRPG
GRVLACGHRF TKLYGAFNLR QMIGRCYLRG NDLQYDENDS NWQDPEQSCS HLGDFTGEVM
CGMGMSAAIT QSEVIVGSPG SFEWQGNIHV SWMNPDDEFD TKKSSFSNQK HRNIYIGYSV
AQAPRLLSED DETIVTGAPR DRMEDAHGSV LLAVKRSDKL MIRQKLHGQQ MGSYFGNALA
IADLNNDGWN DLLVGAPFYF HRQAEVGGAV YVYMNVGGRF NSETSMVLKG PAGSAFGMAV
AAAGDLNQDG YQDFAVGAPF HEAGSVMIWT GSSEGISTEP SQVIRGSMVS PVFGTFGYSL
SAGGDVDGNY YPDLLVGSLD DTIVLFRSRP VIHLNKTLRV SPTIVDPNSC DFCIQVEVCF
FYMFNRGEKS DRDNITILFT LTADITSVKP RLNFRDNGQS VYSDYLSMPR EQCRTLRVGL
QSIIRDKVEP LVFSLNASLY EKFPKKKKNV QDLKRLPVLS ETPRPIRTQI HIQKACGSDN
RCHSNLQMTA RFTDESQQAF PELEGTQVLY FNSTIKRLFL EVNVSNTPST GRPAEDAHNT
ILSISIPPSL IYSGVETKGD ASAVVECSVE GTSLQCELGN PFRSNNKVQV LIKFQPSEIS
LDTREIQSVL QLFTLSEQPD LSPVSVSMVV EYLLQTSLSL ISTSGPTSFS GHVIGEVAMK
KTEDIGSLLL LTFQVHVQGK PLGHLGTLEV EFDWPMEATN GKWLLYLTEI QINGTSEPRC
SPPGNIINPL NLTLSKEEKK KMKRNLDEVN EEEEQTDRTP TVLHMQRKKK RYSLDCVRGA
RCVKFVCPLV SMNNSATLTV KARLWNSTMI EDYSDASSVL VQGRASLKLQ TNKPTVNMES
HSSQIEVYIY SDLGLQVDSG APLWIIMLSA LAGVLLLALI CLLLWKCGFF VSQGVWRAVV
LHQGRIMGKD NLQQQHMDAD GFLIQDQVSS CRNRKSPKHW VTSWTETH
//
