ID   I3JS74_ORENI            Unreviewed;       341 AA.
AC   I3JS74;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Transmembrane and coiled-coil domains 4 {ECO:0000313|Ensembl:ENSONIP00000011719.2};
GN   Name=TMCO4 {ECO:0000313|Ensembl:ENSONIP00000011719.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011719.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000011719.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMCO4 family.
CC       {ECO:0000256|ARBA:ARBA00009824}.
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DR   AlphaFoldDB; I3JS74; -.
DR   STRING; 8128.ENSONIP00000076306; -.
DR   Ensembl; ENSONIT00000011728.2; ENSONIP00000011719.2; ENSONIG00000009323.2.
DR   eggNOG; KOG2385; Eukaryota.
DR   GeneTree; ENSGT00390000001400; -.
DR   HOGENOM; CLU_016865_0_1_1; -.
DR   TreeFam; TF312951; -.
DR   Proteomes; UP000005207; Linkage group LG20.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   341 AA;  36660 MW;  38390283EE53735B CRC64;
     MASLFGAAGA GLTGYKMNKC VGAIEEFEFL PLNSGKHLHV TIAVTGWLCS GKYSSFQAPW
     GSLGECGEQY CLVWESRFLR DLGSAMTSLL DGLVSMVAQE ALKYTVLSGI VTALTWPASL
     LAAASVIDNP WCVCLNRSAE VGKHLAQVLR SRQQGKRPVS LIGFSLGARV IYYCLQELAS
     DQGSEGVVED VVLLGAPVDG SEKAWERMAK VVAGKIVNGY SRGDWLLGFL YRSSAAQLSV
     AGLHPINIQD QRIINVDLSS VVKGHLDYMR QMDTILVAVG VPTKEVPGAS FAIPQSVTVT
     KGTVGIADET TNERQRLHES RHTHTAASSE NPLNELFCLT A
//