ID I3JSN3_ORENI Unreviewed; 324 AA.
AC I3JSN3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011878.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011878.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004473}.
CC -!- SIMILARITY: Belongs to the TMEM120 family.
CC {ECO:0000256|ARBA:ARBA00009700}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3JSN3; -.
DR STRING; 8128.ENSONIP00000045496; -.
DR Ensembl; ENSONIT00000011887.2; ENSONIP00000011878.2; ENSONIG00000009452.2.
DR eggNOG; KOG4758; Eukaryota.
DR GeneTree; ENSGT00390000007848; -.
DR HOGENOM; CLU_048749_1_1_1; -.
DR TreeFam; TF313552; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 324 AA; 38680 MW; 7907F1CB0F5E32BD CRC64;
FLCPSYLDTH RLYKQKLEEV TKLQDSCSNA IARQRKKLKE LTVCKSNSST AKLIPEEEDA
IAEIEDSIKD RAHTFFEMEA FLPKRNGLYL NLVLGNVNVT LLNKQSKFAY KDEYEKFKLV
LTVILFVFSF TCRFLLSYRV LDALFNFLLV WYYCTLTIRE SILISNGSRI KGWWVFHHYV
STFLSGVMLT WPEGALYQMF RNQFLSYCLY QSFIQFLQYY YQSGCLYRLR ALGERHNMDL
TVEGFQSWMW RGLTFLLPFL FFYHFWQLYN SITLFRMFQL PECKEWQVFM CGCSYLVLFM
GNVFTTLAVV YQKYMNNQDK SKNV
//