ID I3JSV4_ORENI Unreviewed; 414 AA.
AC I3JSV4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
GN Name=LOC100695864 {ECO:0000313|Ensembl:ENSONIP00000011949.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011949.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
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DR RefSeq; XP_019219617.1; XM_019364072.1.
DR AlphaFoldDB; I3JSV4; -.
DR STRING; 8128.ENSONIP00000064036; -.
DR Ensembl; ENSONIT00000011958.2; ENSONIP00000011949.1; ENSONIG00000009511.2.
DR GeneID; 100695864; -.
DR KEGG; onl:100695864; -.
DR eggNOG; KOG1868; Eukaryota.
DR GeneTree; ENSGT00940000155545; -.
DR HOGENOM; CLU_008279_1_2_1; -.
DR OMA; EKSKRMW; -.
DR OrthoDB; 227085at2759; -.
DR TreeFam; TF106277; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF101; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT DOMAIN 70..402
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 414 AA; 47348 MW; 54CD3A719BD24141 CRC64;
MTLQSFYRTT NMPSLRHSYT LTVPEDPAAL PYDRPEMRRR SHPLSRSVLV STFMGLIINQ
AKNKSLQGLV GLRNLGNTCF MNSILQCLSN TLELRDYCLR NCHITDLNNN CRSNTALIEE
FAKLTQSLWT SANNEPISPS EFRNQVQRCA PKFVGCNQQD AQEFLRFLLD GLHNEVNRVT
VRPKVSVLDF DHLADDEKGR RMWNMYLARE DSKVVDLFVG QLKSSLTCTA CGFRSTVFDP
FWDLSIPIAQ KISGEVTLKD CLRLFTKEDV LDGEERPTCT KCKARRKCTK RFSIQKFPQI
LVLHLKRFSD SNVRASKLST YVNFPLKDLD LREFASEPSE RPVYNLYAVS NHSGNALGGH
YTAYCKNPAL GEWYSYNDSR VSPMSSSQVR SSNAYVLFYE LATPSHSKYQ TCRL
//