ID I3JUR1_ORENI Unreviewed; 2281 AA.
AC I3JUR1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Zonadhesin {ECO:0000313|Ensembl:ENSONIP00000012606.2};
GN Name=LOC100696410 {ECO:0000313|Ensembl:ENSONIP00000012606.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012606.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000012606.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000042179; -.
DR Ensembl; ENSONIT00000012616.2; ENSONIP00000012606.2; ENSONIG00000010024.2.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000163883; -.
DR HOGENOM; CLU_001167_0_0_1; -.
DR TreeFam; TF316399; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd06263; MAM; 4.
DR CDD; cd19941; TIL; 2.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR025615; TILa_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF123; MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF00629; MAM; 5.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF12714; TILa; 1.
DR Pfam; PF00094; VWD; 4.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00832; C8; 2.
DR SMART; SM00137; MAM; 4.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57567; Serine protease inhibitors; 2.
DR PROSITE; PS50060; MAM_2; 5.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..2281
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025411864"
FT DOMAIN 80..172
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 222..399
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 603..783
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 893..1050
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1077..1233
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1295..1452
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1532..1689
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 2071..2281
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 1242..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2138..2161
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2281 AA; 250474 MW; 71B7A13229ABCFA5 CRC64;
MLGGIRTDLV VTVAVLFLTQ TGTQCRAEND FLLVTLPEWR AHSEYVIQCF DDRRANLNCD
WTASEKGAGD FAVNVSESGP LGIEGKACLE FWYLVPVAAN GSELRVLLKN SVGSVEIWTS
PALPQNAWRQ AFVPLNITEP GSQVVFEAVQ GLSIEKEITF KQIGVRKGSC GQQCESNTEL
WTDVTTRCLC SAGQLSCFPS QCPKGQLCGP QRGGPNGTST FGMCTIHSQA DGSTFDGVLF
RFTTACTYVL AKTCSPTETL PMFTVEVVNE QNDNTSLPQV QKININMRIY RVSLLKSQTD
RVVVNGIWRK LPLSLNSGTV NIRSNPATIV LATTFGLIVS FDSTGVVHVT LPSTYSDKVC
GMCGNFNNHK EDDFGNLNAQ NATALAESWQ TGEPASSCET ILFPQCDPVE EAEYASEQYC
GGLFSTTGPF ADCLSVVGAD SYIRGCVFGM CSTRGDPAVL CETLQVYTDI CNKAGIAVPM
LRNSTLCPIQ CGENSHYNSC ADGCPEVCSN LDIAGSCGSC VARCECDSGF KLSGEKCVPA
EDCGCWYNGK HYEKGETLVE GDCVQQCQCM GNNNVQCTQM QCADNEVCKV KDGVKGCFLF
KPTTCSVYGD PHYITFDGLA YDFQGGCSYI LTTTCGGGSS VQFTVSGHNT HPPLQNFTRS
KLQAVALQVE DLYLILNQSG EVYVNYKQVQ LPYSTKGTYG SVWVYVKNNH IILETTFGLK
MQIDGENRLF LQVDEHYKYE LCGLCGTYSG YQDDDFVTPG GQNVSEAFEF GDSWRVPNNS
ECLARPNNPR LCDKDEKDTA YNECSVLFGS GFMPCHEHIH PSIYLNSCVY DYCATSGDQH
TLCESLKSYA TACQVSGVEL PNWQTGTACE DLSTSTAPPT TASPTPDQTF CPLNCNFEKD
LCGWEQLMQD TFDWTKHSGP TPTNLTGPNQ DHTTGAGFYM YLEGDSVTHG DSARLMSSAC
NFNGPLCLYF WYHMYGSATA MALNIYLLKD SKTTKLWSMM DNQGPEWHLG RADVKVSGPF
QIIIEGIRGS NYQSDVAIDD ISIHFGSCSD GFPVLGSGTK PSTTTTEMLP LHQICNLDCN
FDSNLCSWNQ MITDAFDWTW QRGSTPTLMT GPSADHTGDG HYLYIEANSA TYGDTARLIS
SECSDSGPQC LQFWYHMYGT ADTMGLHVYL LQNRIANQIW RKQNDQGNMW HLAQVDIEPT
TAFQIIIEGR RGSNDQSDVA IDDLKLYRGH CSNLVGGITT QSARPDLNTT TPPSVTVQTT
AAPQPPMVTT TFQPPIINTT VPSNNRPPLQ PVCQLHCNFE QDLCQWNQLI TDAFDWTRQS
GSTPTINTGP STDHTTGGGH YLYIEANSAT YGDTARLISS ECSDSGPQCL QFWYHMYGTA
DTMGLHVYLL QNRIANQIWR KQNDQGNMWH LAQVDIEPTT AFQIIIEGRR GSNDQSDVAI
DDLKLYHGHC SDLVGGITTQ SARPDLNATA PPSVPVQTTA APQPPMVTTT FQPPMINITV
PPIVEETTNL INKNNVTEAP DNRPPLQPVC QLHCNFEQDL CQWNQLITDA FDWTRQSGST
PTINTGPSTD HTTGGGHYLY IEANSATYGD TARFISSECS DSGPQCLQFW YHMYGSADTM
GLHVYLVQNR TANQVWKKQN DQGNMWHLAQ VDITATDNFQ IIFEGRRGSN TQSDVAIDDV
SLHRGRCAEL VNPTTTTTQS KPQTTARPQP STTTQLKPET TAGPQPSTTT QLKPETTAGP
QPSTTTQLKP ETTAGPQPST TTQLKPETTA RPQPSTTTQL KPETTARPQP STTTQLKPET
TARPQPSTTT QLKPETTAGP QPSTTTQLKP ETTAGPQPST TTQLKPETTA GPQPSTTTQL
KPETTARPQP STTTQLKPET TARPQPSTTT QLKPETTAGP QPSTTTQLKP ETTAGPQPST
TAGPQPTINK PQSTTARPQQ TTLPVPTPSC PRYSHYTTCV PACSPTCVFL NGPPHCSDNG
VCVPGCVCDD GFVMKMKICV PLERCGCVDK NGTKHQFNEQ WYTDHCSQKC ECEEDDGIGK
IDCDDEDECD GNAVCLQNEK GNYYCHSTDF DECTIKKDPE YRTFDKMKHD FEGEDSYVLV
RTSNLPNNLP DVYIESINTP VLDQGGDSQH ENDSSSEEEQ NSKDDDDDDD DDDDDDDDDD
SKEHDEHHRL QELKIRVYNH TMEFKKNRKL IVDGKPTDTP VSVTGGLKIW KRSSRIYLQT
DFGLSVAFNG HHSAEITLPH IYRSKVGGLC GNFDAQKNND RMKPDGTIAR STQEFGESWR
V
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