ID I3JVU5_ORENI Unreviewed; 946 AA.
AC I3JVU5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Sorbin and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSONIP00000012990.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012990.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000012990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013124452.2; XM_013268998.2.
DR AlphaFoldDB; I3JVU5; -.
DR STRING; 8128.ENSONIP00000061630; -.
DR Ensembl; ENSONIT00000013000.2; ENSONIP00000012990.2; ENSONIG00000010334.2.
DR eggNOG; KOG4225; Eukaryota.
DR GeneTree; ENSGT00940000158658; -.
DR HOGENOM; CLU_003951_1_1_1; -.
DR TreeFam; TF320680; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR CDD; cd11780; SH3_Sorbs_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14167:SF64; SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 171..228
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 503..562
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 577..638
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 885..946
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 46..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..772
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 105486 MW; C9344EE4B9FCD4FF CRC64;
MKGSPDLIPT PDLDPSRVCK GKGVVTLRAT LVHIDDEDCI SDEPNVISTP SGWTSQINGD
SSKAGLAEGG SNDTADLPPV NNTLCQNNSS ESIKENRAPF FTDVQNSVTS TPSSVYPCTS
IVNPTIVLLQ HNREQQKQLS HSEDPTPERD KSPESRSETV SPVPEMDGKR QRLSLHSPVL
SPLNKPIVPV RNTEKSKDWY KTMFKQIHKI PEPIEENPYR PTYIFPESYE IQVKSKDDGP
TPFGYLEDVR AVPRSKSENE VDSRGRSMPV PMRSSSLKPS AKRNEWEPPD IKVDTRKYRA
EPKSIFEYEP GKSSVLKLER TTQDVSPEDV DLENEPWYKF FSEMEFDKAS APSFSPLETA
SDLQQYSSSK SGHSEVEKDR GSSTDEPVAP ECDRHVYKSV LEGGDIPLQG LRALNKRHGS
SSSSKDSSPA HGESQDEVLR RRHGDKEKIL EEQRRLKREQ EEADTASRRH TSIVPTHHQF
ITNERFGDLL NITDNTEKRK SGIEKTPAMA RFDFRAETLK ELPFQKGDIV YIIRQVDQNW
YEGEHHGRVG IFPRSYVELL PPTEKAQPKK SAPVQVLEYG EAVARFNFTG DTVVEMSFRK
GERITLIRRV DENWYEGKIS GTNRQGIFPV TYVEVHKRPR VKNGVEYPDP PVSHSPQRST
NASPQLYRNR LTTSPLPLPR SPRRSVSPEV HAVSSEWISL TVGGGSPPAA PTPPLPPLPT
VSYRWGEYLP PPFSASPVPP ITGSPYCVSP MASPSASPLP PPYPPRPNST TPSLTFTPPQ
GEDFLLSPSS PHVSRSVSPS SGPVLECWLR GEKELTEGEG AEGDRGRAGP GSRRNSPAEF
VKNEADHHGR STRSPVMLFD IQDNNNVNSF AQPQSHSSSP EPSRLNCGIF QALYSYVPQN
DDELELQEGD LVSVMEKCDD GWFVGTSKRT KQFGTFPGNY VKEVKL
//
