ID I3JWC8_ORENI Unreviewed; 436 AA.
AC I3JWC8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=E3 ubiquitin/ISG15 ligase TRIM25 {ECO:0000313|Ensembl:ENSONIP00000013173.2};
GN Name=LOC100700911 {ECO:0000313|Ensembl:ENSONIP00000013173.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013173.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013173.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005471114.1; XM_005471057.2.
DR AlphaFoldDB; I3JWC8; -.
DR Ensembl; ENSONIT00000013183.2; ENSONIP00000013173.2; ENSONIG00000010479.2.
DR GeneID; 100700911; -.
DR KEGG; onl:100700911; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT01100000263516; -.
DR HOGENOM; CLU_013137_0_2_1; -.
DR InParanoid; I3JWC8; -.
DR OMA; PNEVECD; -.
DR OrthoDB; 5343881at2759; -.
DR TreeFam; TF351086; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF36; E3 UBIQUITIN-PROTEIN LIGASE TRIML1-RELATED; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 13..56
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 146..186
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT COILED 201..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 259..296
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 436 AA; 49649 MW; 2494F03C2820AF6B CRC64;
MAESCEVLHS FSCSICLDVL KNPVTLHCGH SYCMDCINGC FDQEDQSGIY SCPQCRHTFN
PRPVLKKNTV LVDLMVKMSV RAQTNMRVKD EAGPGDVECD FCTVRKLKAV KSCLVCLASY
CATHLQPHYK SAAFKRHKLV EVSASIQEKI CSKHDKLLEV YCRSDGQCIC LLCVMDEHKG
HDTVSAAAER KEKQKQFGKK KQRIQQGIQE KEKQLRQLRQ KTKGLKASSD AAVAQNEKAY
AEIVLKADKR RCAVNDLIRD QEKAALSRTE ELVDRLEKEI SELRKQEDQL KQLSLTEDHI
NFLQHCQTIF DSTEPDVSSD VNLQLHTPFD FVTKAISDLR DKMESVAKCI AQISETIQVD
PDPKTREEFS MYSCCIALDP NTAFENLLLS DGNTKVTWVK NPQRYPYHPD RFTKYALRVY
LVFATGRLNG RGHGWR
//
