ID I3JWZ5_ORENI Unreviewed; 252 AA.
AC I3JWZ5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Transmembrane p24 trafficking protein 6 {ECO:0000313|Ensembl:ENSONIP00000013390.2};
GN Name=TMED6 {ECO:0000313|Ensembl:ENSONIP00000013390.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013390.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013390.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
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DR AlphaFoldDB; I3JWZ5; -.
DR STRING; 8128.ENSONIP00000013390; -.
DR Ensembl; ENSONIT00000013400.2; ENSONIP00000013390.2; ENSONIG00000010650.2.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00390000010961; -.
DR HOGENOM; CLU_066963_5_1_1; -.
DR InParanoid; I3JWZ5; -.
DR OMA; WHFAHQG; -.
DR TreeFam; TF313000; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF45; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..252
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025657187"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..141
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 252 AA; 29048 MW; 4BF616652B6D3B68 CRC64;
MLCWIPCFFL GFLFWGSAHG VPQTNARPDV TDQELFWGSD QYDFAIVLPA AGLECFWHFA
HHGERFYLNF MLLVIPAVCG LGHDRHLSVT VNAPSDLLLS TIDDAKGQIN FEAAESGFYQ
MCFSNFHNRF GAMQISLSFG VYYDTYQDPS KSEEEEKKKK EEISKELNNT LSVIEITTHK
VETYVFHMFR YYGFSRMRKS VDYFLLQSNS KYITWWSMAL SLLIVTSGYL QLLFLKSLFV
SNTGTEGEKP RC
//
