UniProt: I3JXD4

Database: UniProt
Entry: I3JXD4_ORENI

LinkDB:  I3JXD4_ORENI 
Original site:  I3JXD4_ORENI

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Ontology (4)   
   GO (4)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (14)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (3)   
   SMART (2)   
All databases (24)   

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ID   I3JXD4_ORENI            Unreviewed;       472 AA.
AC   I3JXD4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=RAR related orphan receptor B {ECO:0000313|Ensembl:ENSONIP00000013529.1};
GN   Name=rorb {ECO:0000313|Ensembl:ENSONIP00000013529.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013529.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000013529.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|RuleBase:RU004334}.
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DR   RefSeq; XP_005473205.1; XM_005473148.3.
DR   AlphaFoldDB; I3JXD4; -.
DR   STRING; 8128.ENSONIP00000013530; -.
DR   Ensembl; ENSONIT00000013539.2; ENSONIP00000013529.1; ENSONIG00000010762.2.
DR   GeneID; 100711296; -.
DR   KEGG; onl:100711296; -.
DR   CTD; 6096; -.
DR   eggNOG; KOG4216; Eukaryota.
DR   GeneTree; ENSGT00940000157708; -.
DR   HOGENOM; CLU_007368_2_0_1; -.
DR   OrthoDB; 3475284at2759; -.
DR   TreeFam; TF319910; -.
DR   Proteomes; UP000005207; Linkage group LG12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06968; NR_DBD_ROR; 1.
DR   CDD; cd06939; NR_LBD_ROR_like; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR044101; NR_DBD_ROR.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR003079; ROR_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR   PANTHER; PTHR45805:SF6; NUCLEAR RECEPTOR ROR-BETA; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01293; RORNUCRECPTR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          7..82
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          221..459
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
SQ   SEQUENCE   472 AA;  53252 MW;  7E57020A06DDFA9B CRC64;
     MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR NCLIDRTNRN
     RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH QARLQEQRQQ QTGEAEALAR
     VYSSSLTNGL STLNHEIGGT YANGHVIELP KGGHGNGAGV PGGYYGMDST QPSPDQSGLD
     MSGMKHIKQE PVYDLTPVPN LFSYGGYQET QLGPNNVSMG ELDRIAQNII KSHLETCQYT
     TEELQQLAWQ THSYEEVKMY QSKPRDVLWQ QCAIQITHAI QYVVEFAKRI SGFMELCQND
     QILLLKSGCL EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGCDDLVS AVFDFAKSMC
     SLQLTEEEIA LFSAAVLIST DRPWLMEPRK VQKLQEKIYF ALQHIMQKNH MDEDALAKLI
     SRIPTLSALC TLHTEELQAF QQLHPETVNV LFPPLYKELF NPDPNSAMAM PK
//

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