ID I3JXW0_ORENI Unreviewed; 1457 AA.
AC I3JXW0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=GTPase activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSONIP00000013705.2};
GN Name=gapvd1 {ECO:0000313|Ensembl:ENSONIP00000013705.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013705.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013705.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR STRING; 8128.ENSONIP00000073791; -.
DR Ensembl; ENSONIT00000013715.2; ENSONIP00000013705.2; ENSONIG00000010891.2.
DR eggNOG; KOG2319; Eukaryota.
DR GeneTree; ENSGT00940000156611; -.
DR HOGENOM; CLU_002165_1_0_1; -.
DR TreeFam; TF105908; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 144..352
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1317..1457
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 450..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..859
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 162159 MW; 44B64EED16B4E3A9 CRC64;
MVKPDIHTLA HHLKQERLYV ASEKQLIQRL NSDVLKTAER LYRAAWIAKQ QRINLDRLIL
TSAEASPAEC CQHAKMLEDT QFIDGYKTLG FHETIYGEFL ARLRENPRLV ASCLVAGERL
NQEHTQGAIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
LFKLFSEGLY SAKLFLTATL HEPIMQLLVE DEDHLETDPA KVTERLTPAQ QERFGEKGSE
GYKQRVQAAV EANEAKLVAL VTKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVERLEVGE
VRTMCTDLLL TCFICPAIVN PEQYGIISDA PINEVARFNL MQVGQLLQQL AMTDDDADPR
RKSSLSKFDK SCVAAFLDVV IGGRAVETPP MSSMNLLEGL SRTAVYVTHN QLLSLVEFVR
GLMTGDHLRE EEHMALETLL ANVPQSRTVK SNSLELTPSN TPQLSPATTP ANKKNRLPIA
SARSRSRSNI AQEGEAEASS QESLQELVPE EVLVISLGTG PQTVPGMMSE NEVLNQMADG
AQVDGHADDT KLHGKPDKTL RFSLCSDNLE GISEGPSNRS NSVSSLDLEG ESVSELGAGP
SGSNGVEALQ LLEHEQATTQ DNLDDKLRKF EIRDMMGLTD DRDISETVSE TWSTDVLGSD
FDPNMDEDRL QEIAGAAAEN MLGSLLCLPG TGSVLLDPYG STISETTSEA WSVEVLPSDS
EAADLKQEER LQELESCSGV GSTSDDTEVR EVSSRPSTPG LSVVSGISAT SEDIPNKIED
LRSECSSDFG GKDSVTSPDG EESGHGAHHL TSPPSQADSL LAMFDPLSTA EGSSTGTIVR
PKVHYARPPH PPPDPPIPEA SALGQETRHS LFTPHCLAQS ELEHTKQRHS FPDRLVRSRS
SDIVCPGRRP TSDPGLNRRV AVEERDPAGA FALGPSSSPS KDSLKGEVED RKDSDDEKSD
RNRPWWKKRF VPAIPKVLYW TAESEVPAPI AAFRKRDKQE KDEVVHNIPQ DDPLLRTSTQ
AQAAEDILDK YRNIKRISPS DGATAGASYD GAGDLCVEDN VHDAQREDTL QNISADDLPD
SASQTAQQHE TKFSFSDAKK KLRLALCSAD SVALPIMAPA TTRNGLPDHM DPEENEIVCF
LKIQLAEAIN LQDKNLMAQI QETTRCVSRF DARTCRKLLA AIAEDYRKRA PYIAYLTRCR
QGLQTSQAHL ERLLQRVLRD KEVANRYFTT VCVRLLLEHM ECKMLDFIKA FQGCTAADDK
TAAVEDFLRY LYGAMARDAI WQYASEDQLQ DAQMAIERSV MNRIFKLAFY PNQDGDILRD
QLFHEHIQRL SKVVTANHKA LQIPEVYLKE APWPSAQSEI KSINAYKTPR DKVQCILRMC
STIMNLLSLA NEDSVPGADD FVPVLVFVLI RANPPCLLST VQYINNFYAS RLSGEECYWW
MQFTAAVEFI KTIDDRK
//
