ID I3JXX2_ORENI Unreviewed; 837 AA.
AC I3JXX2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013717.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; I3JXX2; -.
DR Ensembl; ENSONIT00000013727.2; ENSONIP00000013717.2; ENSONIG00000010901.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01050000244874; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; I3JXX2; -.
DR OMA; TIQRECT; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..837
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025554094"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..832
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 837 AA; 93882 MW; ADDE2B2C520B95AB CRC64;
MLLQNGWAIL QVLLVVSFSQ ADEQVCRQMG DPENPQLSQD GNIVLGGIFS FYSSWKDRMD
TYLHKPLLNF RGFQFAQAML FAIEEINNST DLLPGVSLGY KIYDACGSMS RSVKVALTLT
NGNEIVAGQS ERPCTRPSQV QAIIGETSSS PCMAIATVLG PFYIPMISHF ATCACLSDKT
KYPSFLRTIP SDYYQSRALA NLVKYFGWTW VGAIRTNDDY GNNGMATFTE TAQQLGICLE
YSVSFFRTDP ADKIQKIIDI IKASTSKVIV AFLSHMDMDV LMYVLSQHNL TEYQWVGSEG
WIFDSQTAAL DKHHILNGAI GLSIPKAHVN GLREFMLNVK PLNSSNNELF TEFWEALFNC
RFRQSKSRAT IQRECTGHED VTGVQNSYTD MSLMPIFNNV YKGVYAVAHA LHNILNPFTH
IKNIDFKTKE GDEVYFNENG DPAAKYEIIN WQPRENGVVE FVTVGLYDIS LAAEKQLNLQ
NKSLIWARNS KQVPVSVCSE KCPPGTRKVL QKGRPVCCYD CIRCAEGEIS NITDSVTCVR
CLPEYWSNER RDACIKKEAV FLSYEEIMGA LLTAASVFGT CTTAGVVLIF FKHRKTPIVR
ANNSELSFLL LFSLTLCFLC SLTFIGQPSE WSCMLRHTAF GITFVLCISC VLGKTIVVLM
AFRAKLPGSN MMKWFGHTQQ RLCVLGFTLV QVIICIVWLT ISPPFPFKNF EEFKDKIILE
CALGSAVGYW AVLGYIGLLS VLCFIFAFLA RKLPDNFNEA KFITFSMLIF CAVWITFIPA
YVSSPGKFSV AVEIFAILAS SFGLLICIFI PKCYIILLKP EKNTKRNMMG KKAPHLF
//
