ID I3JY68_ORENI Unreviewed; 1577 AA.
AC I3JY68;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=DEP domain containing 5, GATOR1 subcomplex subunit {ECO:0000313|Ensembl:ENSONIP00000013813.2};
GN Name=DEPDC5 {ECO:0000313|Ensembl:ENSONIP00000013813.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013813.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000066237; -.
DR Ensembl; ENSONIT00000013823.2; ENSONIP00000013813.2; ENSONIG00000010977.2.
DR eggNOG; KOG3572; Eukaryota.
DR GeneTree; ENSGT00390000016559; -.
DR HOGENOM; CLU_004411_0_0_1; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 1174..1233
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 481..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1498..1512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 176997 MW; EF423729ABE92B97 CRC64;
MKTSKSYKLV LHKKGFGGSD DELVVNPKVF PQVTLGNIIE IAHPTDEYSP LLLQVKSLKE
DLQKETISVD QTVAQAFKLR AYQDVIVNIV DPKDVTLDLV ELTFKDQYIG RGDMWRLKKS
LVSTCAYVSQ KVEFAGIRAQ ASELWVKGEK VTCGYISEDS RVVFRSTSAM VYIFIQMSCE
MWDFDIYGDL YFEKAVNGFL SDLFTKWKEK NCSHEVTVVL FSRTFYNAKT LEEFPEILRG
SIRQDHEGRF YEDFYRVVAQ NERRDEWTSM LVTIKKLFIQ YPVLVRLKEA DAFPVGYNST
AAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM ILTKQRMIDN
GIGVDLVCMG EQPLHAVPLF KLHNRTTPGD SRVGDDYNLP HWINHSFYTS SSQNSCGSFT
PRIKLAGHKL QAEKFKSSKD HTLCVPKDCD NALPIQVDYD AYDAQVFRLP GPSRIQRSTN
FRMGRDKESG RKSWGSVDVS TGIGASPPVR SGGPDEQRSL ASDDSLGPVS NMLLIPRMPT
AQYEVSSSLG YTSTRDLLEK MMDSQRDSSA PGRFTVGSAE STLHIRPGGY TPQRALINPF
TPSRMPMKLT SNRRRWMHTF PVGPSGEAIQ IHHQTRQNMA ELQDSQQRDP AHTSAELLEL
AYHEATGRRS ASRQPGDNGL YPAGGMEEFT GSPGSNNSGT FTNRSSSFQD FSATGADPMP
SFCCTVGVDW KSLTTPACLP LTTDYFPDRQ TLQNDYTEGC YDLLPHSDLD RREDDVPVMS
ASQVFEEFIC QRLMQGYQII VQPNNRKQQP AVATPLGSSP LYSRVFRRRL ARGLVSLRRT
EEEETVYWLS MGRTFHKVCL KDKIITVTRY LPKYPYESAQ IQYSYSLCPP HSDAQFVCCW
VEFGHERLEE YKWNYLDQYI CSGGSEDFSL IDSLKFWRTR FLLLPAGGAR RVADGEGHWD
VYGEGAAAGA GNSGDWVLLD GFIRFLEGLN RIRRRHRSDR IIRQKSAPLK GLQVTSPLSP
YPTEPVAPPQ GKKGTSALSA LLEMEQNQKT LEEQAKPSAA VSDPANVTTA PTYVDSPRKD
AAFILDFIRS PRSSYICHSQ LAAETSEAAD RGVQAGAAAQ PTGDAAACST DVSGQSAGVL
SLSSSSTLME ILEAIKHPTT GVQLLPEQKG LPLNCFISAE VVHWLVTNVE GVATQGMAVD
IMQKMLDEGL VTHASGEAMR TFVYGFYFYR IVGEKDGATP QLSTAAGGGW STAALEDFTL
FQRKWFEVAF VLEERRPCDL PAFLLPWLPS RPASYASRHS SFSRSFGGRS QAAALLAATV
PEQKTVTLDV DVNNRSDRTE WCSCYYHGNF SLNAAFEIKL HWMAVTAAVL FEMVQGWHRK
AASCGFLLVP VLEVPFALTS CLYGDPLRAQ LFIPLNIHCL LKNGSDNLFE GFEPETYWDR
MQLFQEAVLY RFGFVHDKFS ASTFNFPSEN KPQYIHVTGT VFLQLPYAKR KYSSGQQRRR
RNSTTSNSQG PFGGEERVGY YWAYNTMLTK AWRTGVLGDE RLADRLLRDF TDFCGNKDNR
LQSFWDSCQE KMNASAP
//