ID I3JYE0_ORENI Unreviewed; 407 AA.
AC I3JYE0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
GN Name=snx6 {ECO:0000313|Ensembl:ENSONIP00000013885.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013885.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
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DR RefSeq; XP_005477778.1; XM_005477721.3.
DR AlphaFoldDB; I3JYE0; -.
DR STRING; 8128.ENSONIP00000013885; -.
DR Ensembl; ENSONIT00000013895.2; ENSONIP00000013885.1; ENSONIG00000011037.2.
DR GeneID; 100695780; -.
DR KEGG; onl:100695780; -.
DR CTD; 58533; -.
DR eggNOG; KOG1660; Eukaryota.
DR GeneTree; ENSGT00940000154940; -.
DR HOGENOM; CLU_040966_0_0_1; -.
DR InParanoid; I3JYE0; -.
DR OMA; CEKFEQM; -.
DR OrthoDB; 5398040at2759; -.
DR TreeFam; TF313698; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07292; PX_SNX6; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042136; PX_SNX6.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45850:SF4; SORTING NEXIN-6; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT DOMAIN 27..174
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..341
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 407 AA; 46765 MW; E74B770D66F75234 CRC64;
MMQEGLDDGP DFLSEEDRGP RAVNVDLQTD AMLQVDISDA LSERDKVKFT VHTKSTLPNF
KQNEFSVVRQ HEEFIWLHDS FVENEEYAGY IIPPAPPRPD FDASREKLQK LGEGEGSMTK
EEFTKMKQEL EAEYLAIFKK TVAMHEVFLC RVAAHPVLRK DLNFHVFLEY NQDLSVRGKN
KKEKLEDFFK NVVKSADGVL VAGVKDVDDF FEHEKTFLLE YHNRVKDASA KSDRMIRSHK
NAADDINRIA SSLYTLGTQD STDLCKFFLK VSELFEKTRK IEARIAADED LKLADLLKYY
LRESQAAKDL LYRRSRALVD YENANKALDK ARAKNRDVLQ AETSQQLCCH KFEKISESAK
QELIDFKTRR VAAFRKNLVE LAELELKHAK GNLQLLQGCL GILKGNT
//
