ID   I3JYV5_ORENI            Unreviewed;      1701 AA.
AC   I3JYV5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014050.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000014050.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   Ensembl; ENSONIT00000014060.2; ENSONIP00000014050.2; ENSONIG00000011159.2.
DR   GeneTree; ENSGT00940000160652; -.
DR   HOGENOM; CLU_002522_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   Gene3D; 1.10.533.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   SMART; SM00368; LRR_RI; 10.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 3.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          227..363
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          180..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..475
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1701 AA;  189394 MW;  80881F72740B7751 CRC64;
     MDEEVNPDHE NVNSVLAQDS IELFHILSSQ SHSVIMELCQ MMPSEAWHQY QVDPSSSSAT
     ARPELIKTML DYFRSASARK CRNFLQRVCF SCENIPMLLE SRLMSVAGYD NSYENSSPAV
     TDQNSSPPFL EQRLVKRPRI DHWQQYISEV EKCLLKRWKQ LTAGLVREVQ LENVWVSPRA
     ANRSRDRPDQ TPSSADRGGR TPEPDGDYGY LESRVTLETF LQGCLGKVTV LVGKTGSGKT
     LLTSCLGQQW GPVPSSFVFV LLEFRQLNLL SRPLSLSELL FQYYLPPTGG EDAKRAIIDY
     LLTNPEQSCW VLDGYDEFHS KLSKKEVQRK PLHLEDPLPV ADLISGLLNR QILPGSTVLV
     TCRVRDLIDL DGISDKVGQL LGWDQDEIKE YVDNFFGAKA LREQAAQLLL SSRHLLAMSS
     IPALCNICCI CLEHLLLQWR DKATGGAPMP DEKGSKARTD AQEAEGAQMS REARGEEDVI
     MDGTNGRPQL APTSPQVPAT LTQVYLTVLG SFLSRDPNHG GDGRPKTKRF PHSAVTTLTI
     LSQYQSELCE LSRLAWTGLE ESKILFLKEE IPQEVLKFSL RIGLLSQVEL RRQDGILASA
     YCFIHLTVQE FLAALRIMTS NDVNDAQLKK RFSLKTRWTS KSDQKTVFTD SLYLYVCGLA
     SSQCTPALVE LAKVSGSVQS WVQKRQDLVL KLLKTMCNSN TLTGPKILQL CHSVQESQNH
     QLAKQVFGVR PKLELRNIWL LPNDIEALAF VVNSADQNDI GLDFGACSME LECLIVLARC
     QGIHNLSFHS RKYGDKFAEK LSSVLPKFTS LRKLEFSGAS LTATGAASLA SGLQGCPHIT
     EINLSDNNLR DEGISYIAEI FTKLQNLSNV VLGRNSTTLN AVDCLIKTMS SCLNIQHVHA
     DGIKDLTVTF FQKSDMNSLL NQNWNKSEMQ KLAESLARCP ALSVLDLSGG QWDEEILRKL
     TEFLPQFSIT EKIIINDSCS SVEGLVVLTA LLSDYPPVME LHIRYTHASN LSNHSSFASF
     SLSYCNLHPA DLESVLRCLG TSSDLTMLDL SSNCLGNKGL KKLLDFLPRL CKIQEINASN
     NDINMEGVVM LAGALCSYNT LTEIHISGGG KEEVSLKFSP FIFFSRVKDS SILPSDMTKV
     CRKLVQSRFH WELELSQCSL TDEAIGNLLK VLPKMTSLQR LNVSQSITSA ANALKLVSCL
     TDSQRVTSVE LRYSEYFCGT HHTTGDHLKK LLEILQQGPQ LSDLDLSSNQ LEDEDVSSFV
     HSLPRLKIST YVNLSNNRLT QQGLLAVANT LCTCANVSGV EVSLGEEEQC FIWFRQSETR
     EKSLSLVDCA VNGYQLASIE SVIPSCPFLT ELDFSHNILG VEGAEFLCSN MNLYLGWCKM
     LHTVNKHLFT MELFCCSLSH CVLPGGLQLI EALGQCVILE DLCLDSVLLN EESRMCLARA
     LRNINSICRL RLNEIVTAMD NFSVLDLLAA TKGHTHLKEI ELGGWRMACR GIEELNRLIP
     TWTELRKIKL SKNLISDQSG EKLLEALKDC SHLEELCLSD NTLGNLTAAR MALIFPSLTH
     LSVLDISLNR IDHEGSDSLS KAIMCMKNLK KINLTSVGTS ELCAVVASLA HCPLIQEVGL
     GWNNCRDEVA LEVARVLPFC HTLTQIDLEC NSLSVSGAEA LLKALRFCPA LQLIRLWKNK
     IFEGDVHRLA LRDRRMNFSS T
//