ID I3JZT7_ORENI Unreviewed; 487 AA.
AC I3JZT7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Transmembrane protein 145 {ECO:0000313|Ensembl:ENSONIP00000014382.2};
GN Name=TMEM145 {ECO:0000313|Ensembl:ENSONIP00000014382.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014382.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014382.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; I3JZT7; -.
DR STRING; 8128.ENSONIP00000066329; -.
DR Ensembl; ENSONIT00000014393.2; ENSONIP00000014382.2; ENSONIG00000011428.2.
DR eggNOG; KOG4290; Eukaryota.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_021549_3_0_1; -.
DR TreeFam; TF314975; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..383
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 487 AA; 55587 MW; 0EA47594001B589E CRC64;
MVSGLLTTKP QYSLILTDWV FLTRFCFLTE FGRLDFRFRY PKSRCCQNIL LYFDDSSQWP
AVYKRPEKNC YQKEAVLRPE NNQVINLTTR YTWSGCVVRE VLSCVGGRSF RSVRERWWYI
ALSKCGGDGL QLEYEMKLTN GQSFWTQHFS ADEFGILETD ITFLIIFSMV FLLSCYFAYN
LKGRQLLHTT YKMFMTAAGV EVLSLLFHCV YWGLYARDGV GNGSLKILGK LLFSVSFLVF
LLMLILLGKG FTVTRARISH SGSVKLSIYM TVYTITYVIL FIYEAEFFDP GEVLYAYDSP
AGYGLMGLQL VAYVWFCYAV LVSLKHYPEK QPFYVPFFTT YTLWFFAVPV MALIANFGIP
RWAREKIVNG IQLGIHLYAH IVFLVITRPS AANKNFPYHV RTSQIGILLS SPKGGEGAES
FPHHAYGNSS FLGDSQPNFT ELFSIQSVSV NCKFLSCFSA PTGRGVQVSS CNFLRIEPPL
EALDCEN
//
