ID I3K076_ORENI Unreviewed; 807 AA.
AC I3K076;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Semaphorin-3A {ECO:0000313|Ensembl:ENSONIP00000014521.2};
GN Name=LOC100694323 {ECO:0000313|Ensembl:ENSONIP00000014521.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014521.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014521.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; I3K076; -.
DR STRING; 8128.ENSONIP00000037145; -.
DR Ensembl; ENSONIT00000014532.2; ENSONIP00000014521.2; ENSONIG00000011531.2.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000167336; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR TreeFam; TF316102; -.
DR Proteomes; UP000005207; Linkage group LG17.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF71; SEMAPHORIN-3AA; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 3..479
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 512..600
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 671..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 90881 MW; 5D97A72D2B251F6B CRC64;
LKCLTLYLTD MCPCKCFNLI TFNGLANSSS YDSFLLDEER GRLLVGAEDH IFSFDLVNIN
RDNKQVKLSF QIAWPATPSK RDECKWAGKD LGECSNFIRV LQPYNQTHLY ICGTGAFHPI
CAYLEMGKKA EDNIFRLASQ FENGRGKSPY DPKMLSASLL LDGELYSGTS ADFMGRDFAI
FRTLGDHHPI RTEQHDSRWL NDPRFVGIHL IPESDNPEDD KIFLFFKENA MDGEHTGKAT
IARIGQLCKN DMGGHRSLVN KWTTFLKARL ICAVPGVNGI DTHFDELQDV FLMSSKDPKN
PVIYAVFTTS SNIFKGSAVC MYNMADIRRV FLGPYAHRDG PNYQWVPFQG RVPYPRPGTC
PSKTFGGFDS TKDLPDDVIT FARGHPAMYN PVHPIGGRPI MVRTDVDYQF TQLVVDKVEA
EDGQYDVMFI GTDKGTVLKV VTIPRESWHD LEEVVLEEMT VFRQQLYLGS ALGVSQMSLH
RCEVYGKACA ECCLARDPYC AWDGAECSRY FPTAKRRTRR QDIRNGDPLS QCSDLHVEDR
SVFGVENSSM FLECSPKSQR ALIYWQLQKP NDERKVLRTD QGLLIRSLTQ FDTGVYHCQA
VEHGFIQPLL RLNLQVIPTQ RLGDILPGIP GAGGGAGHSA KHRMWYRDFL SLLDHPELNS
VEEFCDRVWK KERKQKRVKT PNSNSQGKPD SAGGSNSALQ PRALAPTAQK QQASPPLSRP
WLQAGDLTVE EPTLSQNTQK GILSSQAPKN NQKTQNGQKG QARLAGSQLA GGSRASSQHA
TKWRRMQENK KGRNRRTHEL QRPPRSV
//
