ID   I3K0W4_ORENI            Unreviewed;      1152 AA.
AC   I3K0W4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=ELKS/Rab6-interacting/CAST family member 1 {ECO:0000313|Ensembl:ENSONIP00000014759.2};
GN   Name=ERC1 {ECO:0000313|Ensembl:ENSONIP00000014759.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014759.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000014759.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_005451728.1; XM_005451671.3.
DR   RefSeq; XP_019202569.1; XM_019347024.1.
DR   AlphaFoldDB; I3K0W4; -.
DR   STRING; 8128.ENSONIP00000074759; -.
DR   Ensembl; ENSONIT00000014771.2; ENSONIP00000014759.2; ENSONIG00000011719.2.
DR   GeneID; 100690550; -.
DR   eggNOG; KOG4809; Eukaryota.
DR   GeneTree; ENSGT00650000093320; -.
DR   HOGENOM; CLU_009304_0_0_1; -.
DR   OrthoDB; 2880381at2759; -.
DR   TreeFam; TF324969; -.
DR   Proteomes; UP000005207; Linkage group LG17.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098793; C:presynapse; IEA:UniProt.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.20.5.2440; -; 1.
DR   InterPro; IPR019323; ELKS/CAST.
DR   InterPro; IPR037245; FIP-RBD_C_sf.
DR   InterPro; IPR019018; Rab-bd_FIP-RBD.
DR   PANTHER; PTHR18861; ELKS/RAB6-INTERACTING/CAST PROTEIN; 1.
DR   PANTHER; PTHR18861:SF1; ELKS_RAB6-INTERACTING_CAST FAMILY MEMBER 1; 1.
DR   Pfam; PF10174; Cast; 1.
DR   Pfam; PF09457; RBD-FIP; 1.
DR   SUPFAM; SSF144270; Eferin C-derminal domain-like; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   PROSITE; PS51511; FIP_RBD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          1082..1144
FT                   /note="FIP-RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51511"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          803..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1025..1047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          176..203
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1030..1047
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1152 AA;  130862 MW;  58C84E963DD9932D CRC64;
     MYGSSRSVSK LDVVGSNGNG SASGSPGRSP RLPRSPRLGH RRNSSSSSTG GLTGTGKTLS
     MENIQSINAA YATGGPMYFT DTAEDPVGVG SLSSGLNPSL PKSTMTLGRA GARVPYGVRA
     AVMGSSPNIN SGGGGGAGSG ALVPSDAIAF GGEMQNQSPQ AATVPHSMRQ VREGAMSDLQ
     TQLREVLREN ELLRRDLEAK ESKLSSSMNS IKTFWSPELK KERALRKDEA TKMAVWKEQY
     RVVQEETQHL QCTIQALQDE LRIQRDLNQL FQSDYSGLGS QPISPQEMTE ENFLRLHAEY
     ERQAKELFLL RKTVEEMELR IDTQKHTLTA RDESIKKLLE MLQSKGLSSR ATEEDHERTR
     RLADAEMTIH QLEGLLEQKD KEMLQLREEL HRRYEAAPES TKTKALQTVI EMKDAKISSL
     ERGMRELEEE VMMLKSNGAL SSEEREEEIK QMEVYRSHSK FMKNKVEQLK EELTHSESEK
     EELRQRANEL QQEVSAVEQA KQELSRKDSE LLALRTKLDT LNNQFSDSKQ HVDVLKESLT
     AKEQRAAILQ TEVDALRLRL EEKESLLSKK SQQISELTEE KSTQQGEITD LKDMMDVKER
     KVNVLQKKIE NLQDQLRDKE KQLSGLKDRV KSLQTDTSNT DTALGTLEEA LAEKERIIER
     LKEQREREER EKGEEVETSK KELKELREKV SQLQAELADR ETSVLDLKEK ASSLASSTLK
     KDNRLKSLEI NLEQKKEECI KLENQLKKAQ SAAAESQANA ELSERISSLE QEVTRYKEEA
     GKAQSEVERL LEILREMENE KNDKEKKIHE LESLASRQMK DQSKKVANLK HKEQLEKSRN
     AQLMEEAKKR EDNLNESSLQ IKDSLRQKEE RIEELEEALR ESVQITAERE VVLAQEEQAR
     TQAEKQVEDL LVAMEKVKQE LEVMKAKLSS TQLSLAEKEG HLTSLRAERR KHLEEVLEMK
     QEALLAAISE KDANIALLEL SSSKKKKTQE EVAALKREKD SLVQQLKQQT QNRMKLMADN
     YEDDHLKVSS PNSEQPNNHK PSPDQILSPL LDLNQNRSKL KLYISHLTSL CQERDPIILK
     DFAPPPAYHR SDSASWHTQL HSMTQEQLEA ELALCEREGT ELQEYANQVL QQIADRCPDI
     LEQVVNALED SC
//