ID I3K179_ORENI Unreviewed; 528 AA.
AC I3K179;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Optineurin {ECO:0000256|ARBA:ARBA00018548, ECO:0000256|RuleBase:RU367122};
GN Name=optn {ECO:0000313|Ensembl:ENSONIP00000014874.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014874.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014874.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act by regulating membrane trafficking and cellular
CC morphogenesis. {ECO:0000256|RuleBase:RU367122}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|RuleBase:RU367122}. Golgi apparatus
CC {ECO:0000256|RuleBase:RU367122}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601, ECO:0000256|RuleBase:RU367122}.
CC Cytoplasmic vesicle, autophagosome {ECO:0000256|ARBA:ARBA00004419,
CC ECO:0000256|RuleBase:RU367122}. Cytoplasmic vesicle
CC {ECO:0000256|RuleBase:RU367122}. Recycling endosome
CC {ECO:0000256|RuleBase:RU367122}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR RefSeq; XP_005460449.1; XM_005460392.3.
DR AlphaFoldDB; I3K179; -.
DR STRING; 8128.ENSONIP00000014874; -.
DR Ensembl; ENSONIT00000014886.2; ENSONIP00000014874.2; ENSONIG00000011814.2.
DR GeneID; 100695341; -.
DR KEGG; onl:100695341; -.
DR CTD; 10133; -.
DR eggNOG; ENOG502QTG2; Eukaryota.
DR GeneTree; ENSGT00530000063808; -.
DR HOGENOM; CLU_034097_1_0_1; -.
DR InParanoid; I3K179; -.
DR OMA; DMKQEMF; -.
DR OrthoDB; 5406882at2759; -.
DR TreeFam; TF326608; -.
DR Proteomes; UP000005207; Linkage group LG17.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd09803; UBAN; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR InterPro; IPR032419; CC2-LZ_dom.
DR InterPro; IPR021063; NEMO_N.
DR InterPro; IPR034735; NEMO_ZF.
DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR PANTHER; PTHR31553:SF2; OPTINEURIN; 1.
DR Pfam; PF16516; CC2-LZ; 1.
DR Pfam; PF11577; NEMO; 1.
DR Pfam; PF18414; zf_C2H2_10; 1.
DR PROSITE; PS51801; ZF_CCHC_NOA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367122};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|RuleBase:RU367122};
KW Endosome {ECO:0000256|ARBA:ARBA00022753, ECO:0000256|RuleBase:RU367122};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU367122};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367122};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367122};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01142}.
FT DOMAIN 498..528
FT /note="CCHC NOA-type"
FT /evidence="ECO:0000259|PROSITE:PS51801"
FT REGION 229..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 22..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 431..458
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 528 AA; 60116 MW; EED9242353755895 CRC64;
MASGGSVMNG DISRSANQPG TLEETLQQMN ILIQENRDLK EALRQTNLTM KERFEGLSAW
REKQKEERDF LESRLEEARG RMEALTLQNQ ELSRRLEETG KTGGAVGGVQ TAELEALRAQ
VARLQAEKND LVALNSELQL KAEHDSQDDS FIEIIKVSDG GVDGMNEALG AERSRRQDAC
MTASRMDNEE VTVSQLLQSL RNEAEKSERL QGELQACTAR IRKLEEKKSN VEEFTQTPEP
ETKEDSAKKD KAASEVENLK AQMMTLYKDL QQAQSKLDEA EGMKKNLQDR CREVEQDVAT
LKAQLVEKQA VQTENDRLKL QLNSMQAQSL MEQRKTAEEK NNLAQLKDAY TKLFEDYTEL
KDEKQRKESH LAEELQQRLT AAEEALAIKQ KKIDEMKQDM FQKEKELETI SVFQAQAEIY
SSDFHAERAA REKLHEEKER LAAQLEYVKK QNTQLQDEMD SMGRRSLNEM QRRHLSQGGN
PHGGGPSLVG RGTDWQHQGN IPEHACPKCN EILPDLDSLQ IHIMDCIN
//
