ID   I3K1A6_ORENI            Unreviewed;       435 AA.
AC   I3K1A6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Family with sequence similarity 172 member A {ECO:0000313|Ensembl:ENSONIP00000014901.2};
GN   Name=fam172a {ECO:0000313|Ensembl:ENSONIP00000014901.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014901.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000014901.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3K1A6; -.
DR   STRING; 8128.ENSONIP00000014901; -.
DR   ESTHER; oreni-i3k1a6; Arb2_FAM172A.
DR   Ensembl; ENSONIT00000014913.2; ENSONIP00000014901.2; ENSONIG00000011835.2.
DR   eggNOG; KOG3967; Eukaryota.
DR   GeneTree; ENSGT00530000063907; -.
DR   HOGENOM; CLU_048484_1_0_1; -.
DR   InParanoid; I3K1A6; -.
DR   OMA; KECNMTK; -.
DR   TreeFam; TF315960; -.
DR   Proteomes; UP000005207; Linkage group LG12.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR048263; Arb2.
DR   PANTHER; PTHR21357:SF5; COTRANSCRIPTIONAL REGULATOR FAM172A HOMOLOG; 1.
DR   PANTHER; PTHR21357; UNCHARACTERIZED; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          221..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  50320 MW;  F9C50FC8534E40D3 CRC64;
     MFYGFTSVIT ERKGPMLFHF CAATPPLFVL WIIMAQVAGQ EDREKTTALK DLLSRIDLDE
     LMKKDEPPFT FPKTLEEFEY AFNEYGQLRH IKTGEPFVFN AREDLHRWNQ KRYEALGEII
     TQYVYELLEK KCNMTKETLP VDATEDEPTG FIYLSPDALS NPSKLLVLIQ GSGVVRAGQW
     ARRLIINQDL NSGTQIPFIE RAMQEGYGVM VLNPNENYLE VEKSTKSPLP SPTETSDEPA
     EKRERKDDKE GKKKKEFYEK YRNPQRETET ERIPIRENGS SEEHVLYVWD HFVSRAAAKN
     VFIMAHSYGG LSFVELMNQR ESEVKNKVCA VALTDSAHNI WLQETTKSTQ DWMQEHCRNW
     VSSPEPLDTT LEPMMPDCPR VSAGTERHEL TSWMSFDSIF RFFSEFHAKE GEEAEETSNS
     VTTRSGSHKN RHQDL
//