ID I3K1W1_ORENI Unreviewed; 2757 AA.
AC I3K1W1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Neurobeachin like 1 {ECO:0000313|Ensembl:ENSONIP00000015106.2};
GN Name=NBEAL1 {ECO:0000313|Ensembl:ENSONIP00000015106.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015106.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015106.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005450030.1; XM_005449973.2.
DR STRING; 8128.ENSONIP00000015106; -.
DR Ensembl; ENSONIT00000015119.2; ENSONIP00000015106.2; ENSONIG00000012000.2.
DR GeneID; 100706724; -.
DR KEGG; onl:100706724; -.
DR CTD; 65065; -.
DR GeneTree; ENSGT00940000155041; -.
DR HOGENOM; CLU_000218_0_0_1; -.
DR InParanoid; I3K1W1; -.
DR OMA; IVFKVME; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1946..2043
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2054..2346
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2550..2591
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 760..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2757 AA; 311241 MW; 12198C8FB04A4F5B CRC64;
MASNERLYEV WMLYCTKRDP DYLKLWLEIF ISSYERCLDV DFEKTPSRPE EVPPVLTLLP
DNILQVLRHQ LLQCVQKASD GLEPEQQNLA LLLLKFLIII CRNLSNVEEI GTCSYINHII
TMTTLYIQQL KSKTKEKEMV DQSQAEEFVR HALAFCESLY DPYHNWRHRT CGEQQMGTVE
RSRQKYKAAP LTVEFVPFFY QCFQESEHLK ESLKCCLLHL FGAIVAGDQR NALLAISPAT
MEVLMRVLAD CSMGSCSSDE GEDWDSEAPD RKALLTLGCL REVVQRLLAS SSDQRQVEIA
SVLENYFKLL NSDPAAVVAA QQQQQQAKGR VPTLGRHWES RFVALQVNML DTIRDMFLCS
DRPVLQAIFL NSNCFEHLTR LLQNSKLVNA RCTAADKDQK DITNNRLLTG ERDTQVFQGR
LDSLAVATIK ALTTVMHKSP AAKEVFKERI GYNHLYEVLI SLGQPSRHLL KELMNMAVEG
EHTSVGLLGI SNVEPLLLLV QWLPELDSSE LQLFTADWLR RLSCLNRQTR ATCVNAAMVM
RALAALERHE RLHRACAESL LGLVGSLGCQ SLSARELLEF LRLLRPPESS QAHPYVGPAL
KALLAMVRKQ GLESAMQYFD LSPSMAGIVV PTVHRWPGSA FSFLAWLSLD QDQLGPSSKD
KRKQLYSFFT PGGTGFEAFI SSAGVLVVAV CTKKEYVTVM LPDYCFCDSL WHSIGVVHVP
GKRPFGQSLV YIYVDGQQKL SAPLKYPTMT EPFTSCCIGS AGQRTTTPPP SQIPDPPFSS
ATTPTTRSSL GGILSPHTWG GLLGGKPESV TKLISAGTQD SEWGSPTSLQ GQLGSVMVFH
EPLQQNHIKA ICSAGPNCIS PFKAQESELG DLSAKLLLHY SPKACRNPIC LDLSPNMLHG
RLTGNKVVNW DIKDMINCVG GLPVLFPILE QLAFVTPDQQ MNDPAGSDFI TPDVTTPADG
DWVILPSNRS SEARLEKNLV ATFLLVLKHF LQRHPINQEN LLYLHGVGTL GALLQKLPAG
HVGVSVLVAV QLLIEQVTYE KNQALLQQLH THLLFNFNIW NKGDFPLRIG HIQYMSTVIK
DNRKQFRKKY GVQFLVDTIR LYYGKNTNKE SDLSEDDVRT IRASLCSLIK YYISKGMSQD
EMQSILGYIA AIGDEDQLCA LLELLLSLLQ SSPAKDQLFL LLFEPAAADS CYALLLNNKH
SDRLRELVFK LFERMLRCDR VYEKNKQRLR LREAGYSGLS LLFSELHITP TLIRCLLNQV
LHTDQVVNYK DLMALVQLTH RAGPSVRLIV CKRVYQLLQS QQDAAAQISK QQCWQDTLMR
LYLRGEGSLA LRSSDTVSTC SLELSRTSGG SNRLELPLER RARAGSAGRL DRVEDDRISI
SDTRSVDSLE NGDVISLLDT PSSSASTEPQ PHVKPWVVGK SGGLMLDLSH LQAYEGGESG
SQTPGSMPST PSPLETSKPF PGNSGDRDAT SSLTEDSFLF SDNISLGESF NNVERAEEEL
CSMLLEIILC VMWRGVEGSD DSAWLERGQV FSALTKLGTA NELLLPVDQI KLSLMERMLE
WAVSDNREAS AATLPQHTEN AVRLLHMVQD FLQAEGLINP ALWTEKVLEE AVTLMDSLMV
WYSSGSQWFQ LSQVGLRLLL GFMAQQDPEV CAMATAKLNG ILQTKEISSQ DEACYLLGKV
EGILRRSIQE QTEEMYSFLV PLLRTLLSKV HRLLYMELHL PQLPDTNGSP SFFDDFKLYC
NSPEWRVYLD KYIIPYMKQY EIEMFSQGHE TMALYWKECY EAFMVSLHKR ERERGESKIR
FQEQFVEPFS RRGRQENLRY NSMLKQQHSQ NNATLRQWKA ARRGLVCERG PWADRHQDEM
HWRVSSAENY SRMRLKLVRN YNFDAHREAS ALRDNLGVHQ QRVNPESLLL EAVKQVKVSD
LEDDILELPE DDPVAANNQV EADEAGQKEK LVLWEDCELV TIVDVVPGRL ELTTQHIYFY
DSSQEKEEGV GHDFKWPLSQ IREVHLRRYN LRRSALEIFL IDQTNYFLNF KKEARNKVYS
RMLLLRSLNL YETRSPQELL KASGLTQKWV NREISNFDYL MQLNTIAGRT YNDLAQYPVF
PWILADYTSE ELDLSDPRVF RDLSKPVAVL NERNAKAVRE KYESFEDPTG TIDRFHYGTH
YSNAAGVMHY MIRVEPFTSL HIQLQSGRFD CADRQFHSIP ATWQTLMDNP NDVKELIPEF
FYFPEFLENQ NGFDLGRLQI SKERVNDVVL PKWAKSPEDF IYKHRKALES EYVSAHLHEW
IDLIFGYKQK GPAAVEALNV FYYCTYEGAV DLDAITDEKE RKALEGMISN FGQTPCQLLK
EPHPVRLSQE EVEKRKAQLD SCPFSMFEHL SDLKSFFVEG ISDNVPLVKV VVPKNQSHSF
ITQGSPDTMV TVSQNCLLGT HGWLPYNKNI SNYFTFIKDP TVSNTKTQRF LSGPFAPGVE
VTAGLFVVSH DGKLLFSGGH WDNSLRVTSL VKGKTVGQHI RHMDIVTCLS TDHCGIHLIS
GSRDTTCMVW QVLQQGGAPV GLHPKPIQVL YGHTDEVVSV SISTELDMAV SGSRDGTVII
HTVRRGQYMR CLRPPCDSSL PLSILHLAVS WEGHMLVHTC LEGKATLKDK NALHLYSVNG
KHLCSEPLME QVTDMCVSGE YVVIGSEQGY LSIRDLYSLS LCAEPMAMRV PVCCVSVTKE
QSHVLVGLED GKLIIVAVGK PAEMRSGQIT RKLWGSSKRL TQISSGETVY NTQQDHN
//
