ID I3K254_ORENI Unreviewed; 342 AA.
AC I3K254;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Sodium/bile acid cotransporter {ECO:0000313|Ensembl:ENSONIP00000015199.2};
GN Name=SLC10A1 {ECO:0000313|Ensembl:ENSONIP00000015199.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015199.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015199.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR RefSeq; XP_003447853.1; XM_003447805.4.
DR RefSeq; XP_005453351.1; XM_005453294.3.
DR AlphaFoldDB; I3K254; -.
DR SMR; I3K254; -.
DR STRING; 8128.ENSONIP00000015199; -.
DR Ensembl; ENSONIT00000015212.2; ENSONIP00000015199.2; ENSONIG00000012075.2.
DR GeneID; 100701737; -.
DR KEGG; onl:100701737; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_7_5_1; -.
DR InParanoid; I3K254; -.
DR OMA; CTMEIFK; -.
DR OrthoDB; 3035577at2759; -.
DR TreeFam; TF315811; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361:SF40; SODIUM_BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 319..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 37160 MW; 4EFC69E6D5C76817 CRC64;
MNLTEVHGGS LSNEANASDN VTLAILNMQG PMNKTVNILT VLNLFITMIS LGCTMEIFKI
KAYLFKPKGV AIALLSQFCI MPITAFSLAK ILQMEPIKAV TVLICGCCPG GTLSNIFSLV
VKGDMNLSIV MTTCSNIAAL GLMPLLLYVF SQGFTGLENA VPYAGILTTL AFTLVPCAFG
IAINHFKPNA AVIVKKVGLS ILIISSIIIC TLSFHIVKNV IWMILMPDAL IAASLMPLIG
FTLGYVMSVL CRLSPQCSRT ISMETGCQNI QLCVAILKVA FPLEVIGPMF LFPLLYITFQ
CAEVFLFALG FRCYQRVKPP AEDTEKQEDQ IVDPQDKEAK RP
//
