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Database: UniProt
Entry: I3K2J2_ORENI
LinkDB: I3K2J2_ORENI
Original site: I3K2J2_ORENI 
ID   I3K2J2_ORENI            Unreviewed;       474 AA.
AC   I3K2J2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   23-MAY-2018, entry version 37.
DE   SubName: Full=Aspartyl aminopeptidase {ECO:0000313|Ensembl:ENSONIP00000015337};
GN   Name=dnpep {ECO:0000313|Ensembl:ENSONIP00000015337};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015337, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000015337}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; AERX01016242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003446617.1; XM_003446569.4.
DR   STRING; 8128.ENSONIP00000015337; -.
DR   MEROPS; M18.002; -.
DR   Ensembl; ENSONIT00000015350; ENSONIP00000015337; ENSONIG00000012175.
DR   GeneID; 100704963; -.
DR   CTD; 23549; -.
DR   eggNOG; KOG2596; Eukaryota.
DR   eggNOG; COG1362; LUCA.
DR   GeneTree; ENSGT00390000003164; -.
DR   InParanoid; I3K2J2; -.
DR   OMA; CFDHEEI; -.
DR   OrthoDB; EOG091G06FO; -.
DR   TreeFam; TF300487; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 2.30.250.10; -; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; PTHR28570; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|RuleBase:RU004386};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Hydrolase {ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Zinc {ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   474 AA;  51870 MW;  558B341937858B29 CRC64;
     MQSLIMKSSK EAVQSAAKEF LQFVNRGVSP YHVVEECRRH LLEAGFIELK ETEQWDIKPA
     SKYFVTRNFS SLIAFAVGGR YLPGNGFSMI GAHTDSPCLR VKPRSKRTKQ GCLQVGVECY
     GGGIWNTWFD RDLTIAGRVM VKSGGKLVNR LVHVSRPLLR IPHLAIHLQR DINDSFGPNK
     ENHLVPIIAT AVQEELETGS ASSGDASSAA STAEKHHPAL VKVLCSELGV EPEALLDFEL
     CLADTQPAAL GGVYEEFIYS PRLDNLHSCY CALRGLMESC TADSLAKDPN VRMITLYDNE
     EVGSESAQGA QSNLTELILS RLASSPSNLT AFQQAAPLSF MISADMAHAV HPNYQEKHEE
     NHRPAFHKGP VIKFNSNQRY ATTAVTASVI REVASQVNVP LQDVMVRNDS PCGTTIGPIL
     AARLGIPVVD IGSPQLSMHS IREMCCTSSV LQSTTLFKGF FELFPTVRST LVVD
//
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