ID I3K388_ORENI Unreviewed; 747 AA.
AC I3K388;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=RNA binding motif protein 10 {ECO:0000313|Ensembl:ENSONIP00000015583.2};
GN Name=RBM10 {ECO:0000313|Ensembl:ENSONIP00000015583.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015583.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015583.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3K388; -.
DR Ensembl; ENSONIT00000015596.2; ENSONIP00000015583.2; ENSONIG00000012370.2.
DR GeneTree; ENSGT00940000160369; -.
DR InParanoid; I3K388; -.
DR OMA; YGHDEQS; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12753; RRM1_RBM10; 1.
DR CDD; cd12754; RRM2_RBM10; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034992; RBM10_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF4; RNA-BINDING PROTEIN 10; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 130..210
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 213..243
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 295..379
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 684..709
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 541..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 82380 MW; 62307A2E3765E6BD CRC64;
MRGGEFNVSF TSFSHILSDK SLTQFFVVSR GGRGDRLGRY GGTHNDHNFR DMDYRGYGQE
DEETGTGFDV RVEGDRQYGN DEQSLGIHDF SPGCLQEHPG FHQRVDGRGE LDQRDQDYRA
ELDHNQRPSN IIMLRMLPPS ATANEIRAQL QEQGIQPREV RLMRNKSSGQ SRGFAFVEFN
LIQEATRWME TNQGVLSILG QRVSMHYSDP KPRANEDWLC NKCGVQNFKR REKCFKCNVP
KSEAELKLPQ VQKDLPIGLQ KEGAQGLLPL PAPYHSSGPP VTPGQAPQQA DVANDTLILR
NLGPHTSVEA ILSALAPFAT LSPSNVRLIK DKHTHLNRGF AFLQLSTIVE ASQLLQILQA
LQPPLSIDGK VIVVEFAKGS KRDVFVTDGS RVSAATVAST AIAAAQWAVT QTTQNGPGGG
QSVDTSVYQQ GAAVTYSQEG LEYAGQDGTT FKPQADNRVA ALTSGVASLN GAYAGGAAPG
LYDMPITVPD VSTYHYDESS GYYYDPFTGL YYDPNSQYYY NSHTQQYMYW DGEKHTYIPA
ASQSNTEGAP PSDGAAPTES PFATSGSKEK KDKPKNKTAQ QIAKDMERWA KSLNRQKENM
RSVSSSPATD DHRESASADA GYAVLEKKGA LSERPQIFLD QIRQSQSPPR QQGLVPAYSG
ETDSEEEGGE KDEKDGRLTD WVKLACLLCR RQFPSKEALI RHQQLSELHK VFLFSSCSDG
ITDTSLGARM LQGGVKRGLL LRNMQVE
//
