ID I3K3J8_ORENI Unreviewed; 1451 AA.
AC I3K3J8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Alpha-2-macroglobulin-like protein 1 {ECO:0000313|Ensembl:ENSONIP00000015693.2};
GN Name=LOC109194179 {ECO:0000313|Ensembl:ENSONIP00000015693.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015693.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015693.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR RefSeq; XP_019212736.1; XM_019357191.1.
DR STRING; 8128.ENSONIP00000015693; -.
DR Ensembl; ENSONIT00000015707.2; ENSONIP00000015693.2; ENSONIG00000012460.2.
DR GeneID; 109194179; -.
DR KEGG; onl:109194179; -.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000162996; -.
DR HOGENOM; CLU_001634_0_1_1; -.
DR InParanoid; I3K3J8; -.
DR OMA; TEDQNIF; -.
DR OrthoDB; 2970602at2759; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF150; ZGC:171445 PROTEIN-RELATED; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1451
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025535965"
FT DOMAIN 468..614
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 747..836
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1359..1447
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1451 AA; 161106 MW; A57422EFEBECE439 CRC64;
MDRLWILSCT LCVLLSWMHV DQAVAEPQYL VAIPAVIDAG AEAKFCATLR QPTGTLVMTV
TLKSREKNTT LFTHTSNEAF QTCVQFEAPL VQKEVQDFQV EVRGDTFYSK QVRKVMIRAS
DTFTFIQTDK PIYLPGQKVN FRVVTMDNKM RPANQLYDVI ELQDPNSNRI GQWLNETSNS
RILQLSYSLD TEAREGPYQI IVSMGERNIS HKFKVEKYVL PKYDVTVNIS EEVLIGQEDV
EAKVCAKYTY GQPVPGRVTV NVCRPINRYS SFSISLYDYD LMALWQMGGS CHAETKQADK
TGCATFSFNM SIFTKMDEKL QDVLDIRAKV KEEGTGVSLP QEKRVTISYV LGKVSFINVP
KIWERGSDVE GKVRAVYHNN TPVCDAPVYL FTGQLWQTRS LQNLTTDSNG VASFSFSTDN
FDGDIQLHAS LTPTLGNPGY RTAHYDRGFH TLSMFQPSSP EIKTISSLEV QKKDKPVSCD
AEEDISVNYT IVGESPGSVD VIYLVLSRGA VTMQGQTQVQ VQDRSVNEGQ VNFQFRVSPE
MSPEFQLVAY AVLPSEDVIA HSANFSTEKC FSNKVSVEFS PSSAIPGEET NMQVTALPRS
LCGVSAIDKS VLIKEPGKTL DADKIFDLLP LKKSSGIPYE VRDAAECLNV RPKRYVLPYP
SQEQNDAYAV FQKVGLKMAT NLVFRLPSCL KFKGKFYHDG SHLVSYGIGS RLSPRVRDYH
VHGLSSLGSA GQLPPPIETA RSFFPETWIW DLVEVGDDGK RGVSLTVPDT ITTWETEAFC
LSSQGFGLAP RKEMKVFQPF FLELTMPYSI IRGEHFELKA TVFNYLTSCI MVTVTPGPSS
DYTLKPLSGD LYTSCLCANE RKTLRWTMIP TALGAVNVTV SAEAVASHVS CDNEVVSVPD
RGRIDVVTKS LIVKAEGTEM TKTYNGLLCP KGNTPIEEAE IHLPENVIEG SARTSVSVLG
VILGRALKNL DGLLRMPHGC GEQNMALLAP NIYILHYLKG TQQLTEAIME KATNFLTSGY
QRQLNYKSDD GAYTTFGTGP GNTWLTAFVV RGFAKAQSFI YIDPRTIEES KTWLEHKQQE
TGCFEKSGEL FNNRMKGGVS DEVTLSAYVT AAFLEMNISQ HDPVMNKSLA CLKESISDLS
NTYTTALLAY VFTLAGDVET RAHLLQHLDT VAVREGGFLY WSQTAAEKSA SLSVEISSYV
LLAKLSVSPT AEDLAYASGI MRWLTGQQNY YGGFSSTQDT VVALQALALY STLVFSPEGW
STVTVQAPSS QLTFDVNQGN KLLYQEEALQ DVSGKYRLEV KGTACASVQI SVHYNIPTPT
DVTTLSVKVQ LEVNTTSESA RPKFSLKIQS LYSGKEKTTN MVILDIKMLS GFSPDPESLK
SLKRGLLVSH VEQKEDHVLV YLEELSKDTP INHSLDIIQE LTVDNLKPAV VKIYDYYHTS
DQAETQYMFV P
//
