ID   I3K3L2_ORENI            Unreviewed;       735 AA.
AC   I3K3L2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Collagen alpha-1(VIII) chain {ECO:0000313|Ensembl:ENSONIP00000015707.1};
GN   Name=LOC100693347 {ECO:0000313|Ensembl:ENSONIP00000015707.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015707.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000015707.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_003446658.1; XM_003446610.4.
DR   AlphaFoldDB; I3K3L2; -.
DR   STRING; 8128.ENSONIP00000015707; -.
DR   Ensembl; ENSONIT00000015721.2; ENSONIP00000015707.1; ENSONIG00000012472.2.
DR   GeneID; 100693347; -.
DR   KEGG; onl:100693347; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00940000154317; -.
DR   HOGENOM; CLU_001074_21_0_1; -.
DR   InParanoid; I3K3L2; -.
DR   OMA; GNEMPHL; -.
DR   OrthoDB; 4272636at2759; -.
DR   TreeFam; TF334029; -.
DR   Proteomes; UP000005207; Linkage group LG23.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24023:SF903; COLLAGEN ALPHA-1(VIII) CHAIN; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 3.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..735
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003673846"
FT   DOMAIN          602..735
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
FT   REGION          63..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..153
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..200
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..569
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  71921 MW;  51E8F9D903067FD9 CRC64;
     MVAVPLHSFY LLITVLQLCL LYLAHGGVYY GHKQPPQQPQ PLPQYDAYPQ QQFLENEMPI
     LPQYGQEFPQ PPLHMGKERP LTDGKGQTFP RGAKGPRPPV PGVKGLPKGL QGIQGPPGPT
     GPPGPQGPPG LPGQGLPGLP GKPGPPGPSG YPGVGKPGMP GLPGKPGGPG LPGSKGDLGP
     NGDVGVTGPP GPPGLPGPSG LPGIPKAGDQ GLPGQRGPLG EPGQKGLPGL PGPPGPKGDK
     GLGIPGFPGL KGPGGPPGPP GQVGIAGIGK PGMNGLPGQP GIPGKPGSPG EPGLAGAPGD
     RGQPGVPGVP GIGKPGKDGF RGQPGVSGGK GEPGLPGLPG NPGLPGYGTP GFPGPKGHKG
     HAGLPGAPGP KGDKGHPGLT GDIGSTGSSG IPGPPGPIGL PGSLGFPGLK GDDGVIGPRG
     NPGVKGQTGP PGLPGQSGRS GEGGQPGPRG LQGPIGPKGE AGVRGLPGAP GAAGLTGTRG
     EGGQAGEKGP QGPQGIPGLT GPGGPIGPPG LPGRKGDAGL PGKPGYPGDG APGPPGLVGP
     QGNPGPSGPP GFPGQPGQPG PPGPPGQPAS FPDLGQILPM TGPYSGQKQG YKNPNGGEIG
     GNGPELPAFT AKLTNPFPPV GSPVIFDKLL HNGNQDYSPQ NGVFTCSIPG IYYFSYNVHC
     KGGNVWVALM KNNEPVMYTY DEYKKGLLDQ ASGSAVLPLR KGDTVHIQLP SEQAAGLYAG
     QYVHSTFSGY LLYIM
//