ID I3K3W1_ORENI Unreviewed; 1923 AA.
AC I3K3W1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|Ensembl:ENSONIP00000015806.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015806.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015806.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR STRING; 8128.ENSONIP00000040931; -.
DR Ensembl; ENSONIT00000015821.2; ENSONIP00000015806.2; ENSONIG00000012556.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_1_1; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000005207; Linkage group LG15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1923
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025646253"
FT TRANSMEM 1273..1296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..319
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..416
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 421..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 519..609
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 614..716
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 721..829
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 830..928
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 929..1024
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1029..1112
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1368..1623
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1543..1614
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1655..1914
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1832..1905
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 400..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1923 AA; 214877 MW; 1B551BFCAC9BE309 CRC64;
MATSGALRIS LQVLLPVITL LLSLLLTGSN ATLPRFTKVP VDQIGVSGGV VSFVCQATGD
PKPKVSWNKK GKKVNSQRIE TIEFDEGAGA VLRIQPLRAP RDENVYECVA ENSEGEIVTS
AKLSIIREDL LPPGFPIIDM GPQLKVVERT RTATMLCAAS GNPDPEITWY KDFLPIDPSA
SNGRIKQLRS GALQIENSEE TDQGKYECVA SNVEGVRYSS PANLYVRELR EVRRVPPRFS
IPPASQEIMP GGSVNITCVA VGSPMPYVKW MLNAEDLTPE DEMPVGRNVL ELSNVRESAN
YTCVAMSSLG IIEAVAQITV KSLPKPPGTP VVTETTATSV TITWDSGNPD PVTYYIIQYR
AKSPDSKYET VDDITTTRYS IGGLYPNTEY EIRVSAVNTI GQGPPSEPVE TRTGEQAPAS
PPRNIKAQIL PQNTMMVQWE EPEEPNGQIK GYRVYYTMDN SQPMSLWQIH NVQDSLITTI
QSLVPQETYT IKVLAFTSVG DGPFSEPIHV KVLQGVPGQP SKFQVGAVSD TSIQLTWEPA
YEKEGIISYE LRYMESTFGG QMKKTFGPTT SYVVEGLRPN TEYRFSLAAI SNKGIGAFTN
DITQKTLQAK PSAPPQEVKC SSTSSTTLLV SWRPPPLESQ NGALVGYRVR YQVVGQSEGA
GDNEEPLEEP MMPATEEQVL LQRLEKWTQY RVTVSASTVI GPGPESEPLV CRTDEDVPGA
PPRRVEVEVI NSTAIKVMWR SLTPGKQHGQ IRGYQVHYVR VENGESRGLP LIKDVMLADA
QWETDDTAEY EMVIGGLKPE TTYSITVAAY TTKGDGARSK PKLVVTKGAV PGPPYLSVAQ
DSETSAVARW DPPDLTNGMD LQGYRLQFGR KDVSPLATLE FAPQERQYSV GNIHRGAIYL
FKISAKSRGG FGEEAVVELN VPENTPGGYP QINEGSNVTC CSVQLSWSPP VLAERNGVIT
EYTLAYKEAG TREAPRELHL PPSLYSYVLN SLKPNSAYDV KIRAHTSVGP GPYSPPIQYR
TVAFDPADVP KNFTVKWATK STAVIAWKFS ESRSPYKCTI EYNRQKMDVD ARQLKVFVTG
LRPNTTYEFT VICQESINGG QRHRVIARTA PLMLTRKPKL DIYSSSDNAL TMSFPSVDSK
DVKNFYVVVV PLKKTPGTVK NLKSPDEIDI EELLREVNPK RRSRRQLAQL DQKKPYIIAC
FRLLPNSFTV GSENRHSNCE NKPLEPGQEY VFFLLAELNA TSGKMFAASP YTDTVVTPEL
VVDPLPVDAG DGLIWVLGPV LAVVFIICIV IAILLYKNKP DSHKRKESEP RTKCLLNNAD
MTPHHPTDPV EVRRINFQTP GMMNHPPIPI SELAEHTELL KANDNLKLSQ EYESIDPGQQ
FTWEHSNLEV NKPKNRYANV IAYDHSRVIL APIEGITGSD YINANYIDGY RKQNAYIATQ
GPLPETFGDF WRMVWEQRAA TIVMMTRLEE KSRIKCDQYW PSRGTETYGM TQVTLLDTIE
LATFCVRTFS LHKNGSSEKR EVRQFQFTAW PDHGVPEYPT PFLAFLRRVK TCNPPDAGPI
IAHCSAGVGR TGCFIVIDAM LERIKHEKTV DIYGHVTLMR SQRNYMVQTE DQYSFIHDAL
LEAVACGNTE VAARSLYSYI QKLAQVESGE HVTGMELEFK RLANSKAHTS RFISANLPCN
KFKNRLVNIM PYETTRVCLQ PIRGLEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW
RMLWENNSTI VVMLTKLREM GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV
TDARDGQSRT VRQFQFTDWP EQGVPKSGEG FIDFIGQVHK TKEQFGQDGP ISVHCSAGVG
RTGVFITLSI VLERMRYEGV VDIFQTVKML RTQRPAMVQT EDEYQFCYHA ALEYLGSFDH
YAT
//
