ID I3K4I6_ORENI Unreviewed; 552 AA.
AC I3K4I6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016031.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000016031.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3K4I6; -.
DR Ensembl; ENSONIT00000016046.2; ENSONIP00000016031.2; ENSONIG00000012737.2.
DR eggNOG; ENOG502QU9F; Eukaryota.
DR GeneTree; ENSGT00950000183145; -.
DR HOGENOM; CLU_002555_11_3_1; -.
DR InParanoid; I3K4I6; -.
DR OMA; DEKGWGW; -.
DR TreeFam; TF329295; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 5.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF27; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 4.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 4.
DR SUPFAM; SSF56487; SRCR-like; 4.
DR PROSITE; PS00420; SRCR_1; 3.
DR PROSITE; PS50287; SRCR_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..170
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 198..248
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 314..414
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 450..550
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 95..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 108..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 139..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 339..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 352..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 383..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 475..539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 488..549
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 519..529
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 552 AA; 59632 MW; 9629C093F3FA2E64 CRC64;
MASQGALRGQ RVVESECRCW NPAVWLLVSL LGTLVLVAIS ILLRLGDIKI SRRALPASGV
QSPVRTEYQV QLVNGRSRCE GRVEVQYNGS WGTVCDDDWD MVDANVVCRQ LGCGVAVAVS
SSSKFGQGTG LIMLDNVDCK GSEMELSQCC SLGWGIHNCY HYEDVGVTCR EPTLPGSRGF
EEPSTPPQSI SGLRDGTIRL VNGQNSCQGR VEIFYQGNWG TVCDDDWVLN NAKGTEQDLT
KCKSLGWGKH NCGHHEDAGV TCTGSTTVPP VATEVQRGLW GTLNTEVPVT KSPSTTTTVT
TTTTTTQTKV TSAIRVINGN SSCQGRVEVL YKNVWGTVCD DDWDMPNAKV VCRQLGCGAP
IAAKSNAYFG HGSGPILLDN VECSGFELEL SQCFHLGWGQ HNCGHHEDAG VICAPFDPQF
FDLASAREFR VTETIPTTTT TTTQPPEGMV RLMGGQHRCE GRVEMYLNSG WGTVCDDAWD
LPDAQVVCRQ VGCGEAIAAR GEAYFGPGMG TILLDNLKCR GTERSLQSCS HISWNVHNCD
HSEDAGVTCL PS
//
