ID I3K522_ORENI Unreviewed; 3572 AA.
AC I3K522;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 {ECO:0000313|Ensembl:ENSONIP00000016217.2};
GN Name=SVEP1 {ECO:0000313|Ensembl:ENSONIP00000016217.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016217.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000016217.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8128.ENSONIP00000016217; -.
DR Ensembl; ENSONIT00000016232.2; ENSONIP00000016217.2; ENSONIG00000012887.2.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000156061; -.
DR HOGENOM; CLU_000343_0_0_1; -.
DR InParanoid; I3K522; -.
DR OMA; RLCLQNK; -.
DR TreeFam; TF342247; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0009913; P:epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0090136; P:epithelial cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0036303; P:lymph vessel morphogenesis; IEA:Ensembl.
DR CDD; cd00033; CCP; 32.
DR CDD; cd00054; EGF_CA; 7.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 34.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02494; HYR; 2.
DR Pfam; PF00354; Pentaxin; 1.
DR Pfam; PF00084; Sushi; 32.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00032; CCP; 34.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 5.
DR SMART; SM00159; PTX; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50825; HYR; 2.
DR PROSITE; PS51828; PTX_2; 1.
DR PROSITE; PS50923; SUSHI; 33.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..3572
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025655447"
FT DOMAIN 93..274
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 386..445
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 446..505
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 506..570
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 569..651
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 652..733
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 734..797
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1207..1243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1245..1281
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1283..1319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1321..1357
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1359..1395
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1397..1433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1644..1702
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1703..1760
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1760..1799
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1802..1859
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1860..1917
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1918..1975
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1976..2033
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2034..2095
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2096..2158
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2159..2216
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2217..2276
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2277..2335
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2336..2393
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2394..2453
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2454..2511
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2512..2569
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2570..2626
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2627..2701
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2702..2759
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2760..2817
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2818..2875
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2876..2933
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2934..2991
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2992..3048
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3049..3107
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3108..3166
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3167..3229
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3292..3347
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3348..3408
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3409..3465
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3495..3527
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3528..3559
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 36..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 416..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 476..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1233..1242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1271..1280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1309..1318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1347..1356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1385..1394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1423..1432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1673..1700
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1731..1758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1830..1857
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1888..1915
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1946..1973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2004..2031
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2098..2141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2187..2214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2364..2391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2424..2451
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2482..2509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2540..2567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2672..2699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2730..2757
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2788..2815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2846..2873
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2904..2931
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2962..2989
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3019..3046
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3078..3105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3169..3212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3318..3345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3350..3393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3379..3406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3499..3509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3517..3526
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3531..3541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3549..3558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3572 AA; 389568 MW; 8D9E211E9D993F48 CRC64;
MFYQRYSLTL SWTTCLLLLC VLDAWTTAWP AVQQSQRQQQ QPRRYRQMST LSSSSSSSSP
GNLSESAESK VERLGMAFKR NVRELREKSS CLDLVFLVDE SSSVGANNFL SELRFIRKML
SDFPVAPENT RVALVTFSSK THVVTRVDHI SAPKSHQHKC SLFNQEIPAI NYRGGGTYTK
GAFQRAAQIL RHSRGNATKV IFLITDGYSN GGDPRPVAAA LRERGVEIFT LGIWQGNIRE
LHDMASQPKD QHCYLVHNFA EFEALARRAL HEDLPTGSYI QEDLSRCASL CEAGKDCCDL
MASCKCGTHT GQYDCICEKG YYGKGLQHEC TACPPGTYKP EGTPGGVSTC LPCPDAQHTS
QPGSTSPNDC VCKPGYTPIG MTCQVIHCPA LLPPEYGFFV QNVCNNHFDA ACGVRCQPGF
DLQGTGIRLC QADGTWSGTP ASCRVRSCPH LSLPQHGFLS CSSSFASYRV ECQVGCDRGY
RLEGDSKLTC QANYQWSGPQ PRCVEVRCPP IVTLKNIFLS PPACGRRAVS PGFVCLLNCR
PGYSLQGNRK AVCLSSGNWT ANVYKAVCTD TEPPWLQCPD NIVAGTVERR GTAIVSWNVP
NATDNSKEEV VVQAKPVYSP PQLFPIGKET ITYFATDRSG NQANCSFTVT VIDTEPPVID
RCRSPPAIQA TNTETAVDWE VPQFSDNSGG RLTVTSSHRP GSLFPVGETL VQYTATDAAG
NSRTCNLTVT VQGTTCDQPY VPVNGEFICS EEEEGVNCTL HCKDGYSLTQ DAVHSYFCAY
NGIWEPAYSP DRPDCSLNRI ANNGFKPFEM LFKASRCDDV DLVKSFTGEF NSKLGGMLPK
ICGNDDVTCK LEVMSQGHCL EYNYDYENGF AIVPGGWGDN WGTQGSQDYA YFESGFATST
RQLPTQNQDD SMQLHHRTKR HRKIKGPTKD HKIQIYFNIT ASIPLPLSRN DSIEVANQKR
LLRMLEQLTN RLKRTLSKQP LSNYHLSSEM IIADPKSLES KRASLFCRPG SVLKGRMCVQ
CPVGTYFSLE YNECESCWLG SYQDQEGQLE CKSCPEGTST AYLHSRSITE CKGQCKPGSH
SRNGLEICES CPLGHFQPSF GARKCEVCPD ETSTVTRGAV DETECGVPCS AGHFSRTGLV
PCYPCPRDYY QPEHGRSYCL SCPFYGTTTI TGATTIQHCS SFGSSFLPKE ESVTDLTSLF
RLLFPQVFHE CFLHPCQNKG TCEEVGAGYV CTCMPGFTGA KCEIDIDECN SAPCQNGGLC
KDGMGDFQCQ CKPGFLGSLC EAEVNECHSN PCLNEGVCVD EVNKFACSCS TGFTGSRCEL
EIDECLSNPC LNGGVCEDMT GGYTCNCAVG FSGDSCEIDT DECYSAPCLN GGSCLDAVNS
FRCQCVEGYR GRLCEVDVDE CDPNPCVNGA SCLDGLGSYT CRCLPGFNGT RCETEMSSAF
NLDFEVSGIH GYVMMDGVMP ALTEITCTFW MRSSDTTNYG TPVSYAVEGS DNAFLLIDYN
GWVLYVNGKE RITDCPAVNT GQWYHIGVSW RSWDGDWRIY INGKPSDGGK GLSVGTTIPA
GGALVLGQDQ DQRGEGFNPV ESFVGSLSQL NIWDRVLTPQ QIKVLASSCP ASHVTHRGNV
LAWPDFLSGV VGRVKVNLNS IFCADCPKLE NTVPHLHVST VDVRPGAQVQ LSCDPGFYLV
GEPVLQCQNR GEWSHNLPSC ERVSCGPPHL LENGFFQGTD FHAGSSVVYE CNAGFYLLGD
TKVHCTNSGK WGGTSPACLD VDECALGSDC DDHASCQNTE GSYACTCIHP YTGDGKNCTE
PVKCENPGTP DFGRRYGSNF LMGSEVVFSC DNGYELIGSS QLQCLETGDW DDAVPYCRAL
SCPAPSVPEN SIMTGNNFTY GSKVTFSCKK GFQPQVPYEF QCLSSLRWTG TPPTCHPVTC
GGPPTVENAD YTLNTNTYLS TVTYTCNEGY RPQGSMEVIC EATGEWSRPF PRCVRVLCSE
PPLLENAVTV GENFELGNKV HYVCKEGYTL IGPETRECQS SGQWSESTAQ CVPRSCGPPP
AIDHAEPYET HKLFGDTANY YCTDGYIAGN NSKMVCNAQG MWVPPDGMEA PRCIANFCLR
PPELPHAILD SVNKPKYASN SEVSYKCEEG FMLNTTATLR CLMGGEWEPS PYDIGCVPVR
CSKPESIDQG YVIGTNYSFG AVVAYSCFKG FLIRGEKRRT CNGNGEWGGA LPTCVPVSCS
HPPSLKNGYF QVKGRLTYNS KVTYACNAGY RLIGRPERVC QANRQWSNQD PPTCVLLTCD
PPPNIVHGHY KGSDFQVGRK VVYVCDEGYE LVGDATWTCL KFGRWDKTRP PRCSPVQCPE
PPLEENHLVL RGLDSESGTV ELSCEDGYVL EGARFLRCTP SQEWNDTFPV CKQVFCDPPP
SVPFGGPSRS SRLLPFSSVV TYTCIGGFTL RKEGSVSCLA NGQWSSPYPE CIPVECPQPV
EISDGIVDVQ GLMYLSKALY SCKTGYNLVG NSTILCGEKG LWIGGVPSCR PIECSIPKQI
TNGKVVYTKL QFDHSATYSC NRGYRLQGTE TARCLASGEW DIEPPACVQI SCTPPQPVEN
GFVEGQDHSY GVTIFYSCFP GFQLVGQDHL TCEEFGWSSS VPVCVPSDCG LPPHIDFGEY
VRVTELGGRF TSKDTGRLDL NFLHGTLIEY RCHRGYDLTS QVRLVCQEDG GWNGTAPSCV
PAECQIPPGP EHGWMNVTHA SLGTTLTYTC DEGYELKGEP VRQCVSGRVW TTDAPVCQPV
SCGDPGAVDN GTTQGGDFVY PEVLHFQCNP GFVLKGSSTI TCQADGKWTG LKPQCEPVSC
GPPKIPGDIT FKGTEFTYNN KIELSCQPGF ILKGRSPSIC QADGTWSHKA VACVSARCEK
PSPILNGRML GSEFGYSSKI KYECDEGYTL NGDSTRVCQS DGLWDKPAPR CDIISCDPPE
DISHGYVNGS SFNYDDIVEY VCFDGYEVVG DPILRCSSQG LWVGPVPQCQ PCICTLPVVK
YGVVLGHDRA CGDRVHFQCN DGYKLLGPSQ AVCEKGGVWS PGVPVCSRGR CTAAPPTVPN
AVLQGGSASY PEMAIYRCRP GYQLKGYAYL TCGRDGRWGE PRIRCEPVSC GKPPEVANAR
VVGDIFSFPN QITYRCDDGY ELATQTASLS CQSDATWSKH NVRCRPTPCL LPNNFSIPHL
VITGKELTPV GGTVTLSCPT GFYLQGSALA ECQVGGSWSP SISSVSCEMV MCEKPPPLLH
GIVEGDSYNY GDFVMYSCLP EFMFCNVLQQ IHILYFNSTA PLTPFFTASS LQSCGAPPTV
QNAQPAGEPS PDNVTYVCNP GLQLVGPETL TCLDNGTWSL PVPTCEAKTC PAPPGWKEDS
SRDRARQEFH VGQSVRVTCP KGQQVKGSST ITCRSDQTWS PISSVCERVS CGPPLHVANG
VVRGAVFQFG DVAVYSCYGG YTMEGVGRSR CLENGTWTPP PTCRAVCWLQ CQNGGVCQRP
NTCSCPEGWM GRLCEEPICI LPCLNGGRCV APYQCECPTG WTGTRCHTAV CTSACQNGGR
CIRPNRCSCP SGWIGHNCSR WLDTPTRTLV TY
//
