ID I3K621_ORENI Unreviewed; 299 AA.
AC I3K621;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=T cell leukemia homeobox 1 {ECO:0000313|Ensembl:ENSONIP00000016566.1};
GN Name=tlx1 {ECO:0000313|Ensembl:ENSONIP00000016566.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016566.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000016566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_003456734.1; XM_003456686.4.
DR AlphaFoldDB; I3K621; -.
DR STRING; 8128.ENSONIP00000016566; -.
DR Ensembl; ENSONIT00000016581.2; ENSONIP00000016566.1; ENSONIG00000013171.2.
DR GeneID; 100695693; -.
DR KEGG; onl:100695693; -.
DR CTD; 3195; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000158698; -.
DR HOGENOM; CLU_053409_1_0_1; -.
DR InParanoid; I3K621; -.
DR OMA; QANRLLM; -.
DR OrthoDB; 380905at2759; -.
DR TreeFam; TF325347; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0050776; P:regulation of immune response; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042247; TLX1/2/3.
DR PANTHER; PTHR45921; IP01054P; 1.
DR PANTHER; PTHR45921:SF2; T-CELL LEUKEMIA HOMEOBOX PROTEIN 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 172..232
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 174..233
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 299 AA; 33160 MW; 1C249E689C1AD4C2 CRC64;
MDHIGILGAH LQQHAQVESI SFGIDQILSN VEQSCMLGTR MHEPDYGHPA YNSGASGGVN
GGFTCNNSGY NGTGSACGMS SLGSAYQMSM GVNMNGANVN PAGVIRVPAH RPLSAGNSSM
PAMSGTINNL TALTFPWMES NRRYTKDRFT VSLSPLTVTR RVGHPYQNRT PPKKKKPRTS
FTRLQICELE KRFHRQKYLA SAERAALAKA LKMTDAQVKT WFQNRRTKWR RQTAEEREAE
RQQANRILMQ LQQEAFQKTI NQPVTPDPLC LQNSSLFALQ SLQPWNENTA KIGSVTACE
//
