ID I3K848_ORENI Unreviewed; 357 AA.
AC I3K848;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Homer protein homolog 1 {ECO:0000313|Ensembl:ENSONIP00000017293.2};
GN Name=LOC100694084 {ECO:0000313|Ensembl:ENSONIP00000017293.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017293.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017293.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; I3K848; -.
DR Ensembl; ENSONIT00000017308.2; ENSONIP00000017293.2; ENSONIG00000013747.2.
DR eggNOG; ENOG502QR3K; Eukaryota.
DR GeneTree; ENSGT00940000156354; -.
DR HOGENOM; CLU_033940_0_0_1; -.
DR TreeFam; TF325627; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF3; HOMER PROTEIN HOMOLOG 1; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..109
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 113..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 182..334
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 121..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 40671 MW; 0B63020F80A4B61B CRC64;
MEQPIYSTRA HVFQIDPNTK KNWLPTSKHA VTVSYFYDST RNVYRIISLD GTKAIINSTI
SPNMTFTKTS QKFGQWADSR ANTVYGLGFS TEHHLSKFAE KFAEYKEAAR LAKEKSQEKM
DMATSPSQES PAGELSSPLT PVTPPMENIN GTDEICDTTP NSDARPEPAQ NALAFAHSPA
MTKHWEAELE ALKGNNAKLT AALLESTANV KQWKQQLAAY QEEAERLHKR VTELECQSNQ
TPVIKSQKTE LNQTIEELET ALRDKEEEME KLKEELENMN DLMEQKDTLT QKLEETELRS
RVLEEQLAGA EQRLEENQEE QENFRKSLRT LLELLDGKIF ELTELRDTLA RLIEEAS
//
