ID I3K8D0_ORENI Unreviewed; 657 AA.
AC I3K8D0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=PR/SET domain 6 {ECO:0000313|Ensembl:ENSONIP00000017375.2};
GN Name=PRDM6 {ECO:0000313|Ensembl:ENSONIP00000017375.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017375.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017375.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_003444552.1; XM_003444504.3.
DR AlphaFoldDB; I3K8D0; -.
DR STRING; 8128.ENSONIP00000017375; -.
DR Ensembl; ENSONIT00000017390.2; ENSONIP00000017375.2; ENSONIG00000013818.2.
DR GeneID; 100709871; -.
DR KEGG; onl:100709871; -.
DR CTD; 93166; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000155852; -.
DR HOGENOM; CLU_032452_0_0_1; -.
DR InParanoid; I3K8D0; -.
DR OMA; AARYRCT; -.
DR OrthoDB; 5342037at2759; -.
DR TreeFam; TF106403; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19191; PR-SET_PRDM6; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044416; PRDM6_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515:SF22; HISTONE-LYSINE N-METHYLTRANSFERASE PRDM6-RELATED; 1.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 295..414
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 535..562
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 563..590
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 591..618
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 619..646
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 30..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 70318 MW; E9666FEB3B66D50C CRC64;
MLKPGDPSGS AFLKVDPSYL QHWQQLFPQA QLKAPLAPPP PPPDRLSIPI DTVRPSRLHS
HLLASTHCTS SSSSSTSSSS AASSSAAAAA AAAAAAAAAA LTPSTSISIS TNAGLSQLPV
PQQIALFGQA LAPVCAGPGG PGGGGGGPGG GGGGDLVVVV PPENPQGLNP AAGLLHQAKE
QSCGGVGVGV VSSSVKSSSS GGSSEEGGKG TVTRFKLTAE ELDYYLYGQQ RMEIIPLSNH
TGELNNRCDM CADNRNGECP MHGPLHSLRR LVGTSSTAAP VTLPDIPDWL RDLPREVCLC
TSTVPGLGYG ICAAQRIPQG TWIGPFQGVP LMLEKAQSGV VRNTRHLWEI YDSEGTLQHF
IDGNDPSKSS WMRYIRCARH CGEQNMMVVQ YRSCIFYRAC MDIPRGTELL VWYNDSYTSF
FGIPLQCIAQ DENLNVPATV VEAMTRQESL QSFSKNGKPS SSSSSSSSSS TPSSTLMRSM
VFPHSPCPRS FSLLDKVGVQ SDSSFGQLGS KNQRVLASPT STSQLSSEFS DWHLWKCGQC
FKTFTQRILL QMHVCPQNPD RPYQCGHCSQ SFSQPSELRN HVVTHSSDRP FKCGYCGRAF
AGATTLNNHI RTHTGEKPFK CERCDRSFTQ ATQLSRHQRL PNECKPVNET SESIEVD
//