ID I3K8K0_ORENI Unreviewed; 814 AA.
AC I3K8K0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Receptor interacting serine/threonine kinase 4 {ECO:0000313|Ensembl:ENSONIP00000017445.1};
GN Name=ripk4 {ECO:0000313|Ensembl:ENSONIP00000017445.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017445.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003457966.2; XM_003457918.4.
DR AlphaFoldDB; I3K8K0; -.
DR STRING; 8128.ENSONIP00000017445; -.
DR Ensembl; ENSONIT00000017460.2; ENSONIP00000017445.1; ENSONIG00000013876.2.
DR GeneID; 100698179; -.
DR KEGG; onl:100698179; -.
DR CTD; 54101; -.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000159908; -.
DR HOGENOM; CLU_015188_0_0_1; -.
DR InParanoid; I3K8K0; -.
DR OMA; HSKENTC; -.
DR OrthoDB; 5295000at2759; -.
DR TreeFam; TF106506; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd14025; STKc_RIP4_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF65; RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 4; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 9.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 24..288
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 435..467
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 468..501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 502..534
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..601
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 602..634
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 635..667
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 668..700
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 735..756
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 284..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 814 AA; 89501 MW; 5D02DE7A55B42537 CRC64;
MDMDVPDSPH GNMGLLRTFD SSEFGSWEKI GSGGFGQVYK VRHVQWKTWL AIKCPPCLHV
DDKDRSELLE EAKKMEAAKF RYILPVYGIC EDPQGLVMEY METGSLETLL ANEPLPWELR
FRIIHETAVG MNFLHCMNPP LLHLDLKPAN ILLDAHYHVK ISDFGLARWN GLSRADDISR
DGFCGTIAYL PPESIIEKDR VSDTKHDVYS FSIVIWGILT QKKPYQGENN ILQIMVKVVK
GVRPDLGAVP RCRPSACTGF LTLMQRCWAT KPEARPSFQE ITSEAEELCS KPQEEPKSPR
LSTSDPEPMT PKALTGDQVN DNKPVRPKSA MLPEKDYSLS ELLSQVDSGI SRSFDRVKED
SCHSKESTCK RLSGISSADS AFSSQDSITL SFEKEGTYDS AEVQKRKLCE AIRNKDTAKL
MKILQPQDVD LLLDGGDSLL HHAINLGNDE AVKFLLLNNA NPNLANARGS TPLHLATEKH
LKSLAELLLG RRSTNVNAKD EDQYTALHWA AQNGDEAITR LLLDRAAAIN ETDGQGRTPA
HVACQHGQEN VFRVLLSRGA DVQIKGKDNW TALHYAAWQG HLGIVKLLVK QAGADVDGQT
TDGRTPLHLA SQRGQYRVAR ILIELGADVH MTSAGSKTPL HVAAETGHTS TSRLLIKHQA
DINAQSAHGL TPLHLASQRG HLPTVKMLIE EGADPYKANS ALRTPCHMAA EGGHCEVLKE
LLHHCPDGAN LSDEQGLSPL HLAVQGGHSN IITMLLPQDC QDLVAESSVQ PAAEEPAAAE
ARHLQRKVVI LKLTEHSDKD CPQSVSAHCA SAPC
//