ID I3K918_ORENI Unreviewed; 658 AA.
AC I3K918;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=PDZ and LIM domain 5b {ECO:0000313|Ensembl:ENSONIP00000017613.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017613.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017613.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3K918; -.
DR STRING; 8128.ENSONIP00000040417; -.
DR Ensembl; ENSONIT00000017628.2; ENSONIP00000017613.2; ENSONIG00000014011.2.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00940000155292; -.
DR HOGENOM; CLU_001357_8_1_1; -.
DR TreeFam; TF106408; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09361; LIM1_Enigma_like; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR031847; PDLI1-4/Zasp-like_mid.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214:SF60; PDZ AND LIM DOMAIN 5 ISOFORM 2; 1.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF15936; DUF4749; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 56..131
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 480..538
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 539..598
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 599..658
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 149..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 71107 MW; 34DF2A5706B6F695 CRC64;
MYLVIHTLHF LFQFRSVQLF KTEKGLNTLL LHSQHQTRLR TARYIMNTNY SVTLDGPAPW
GFRLQGGKDF CLPLTISRLT DGGKAAKAKM SIGDIILSIN GISTDSMNHL EAQNKIKACT
GHLSLTLQRP SAAPPKDGVP KDEPQEIIKP VPITHPSPST TYTKPISQAT PAYNKTARPF
GGGSSGASSS PAAPKVASIP SESSAFTPAA PSQLPQPPFP LRSSQTATDT APASSVPKPS
PGRSTFMSSS TSSSSSNSSS PARMTTTTSH PNVPQPSVYN TPINLYSNSN ACEVAIGQRR
GLLESQGLSE HVNGKATVQP ENHSSPLSDA SKKRLIEDTE DWHPRTGTSQ SRSFRILAQM
TGTENEQTPD NSGKNEAVEK TNPTVHTSPA AKTYSKPAAA PTNGKVVPAS SFKSPAAQNK
APYQPGAPSG FPKGGALPSF GKITNPAPKG PDRPTPRPHP EDLNSLVQRA EHIPAGTRTP
MCCKCNNIIR GPFLVAMGMA WHPEEFNCAH CRSSLADHGF VEEGNQVYCV QCYEQFFAPT
CARCQQKILG EIMNALKQTW HVSCFVCSAC HLPIRGNTFH MEDGQPYCEK DYYNLFGTNC
HGCDFPIEAG DKFLEALGFT WHDTCFVCAV CSTNLEGQAF FSKKDKPLCK KHAHTVNI
//
