GenomeNet

Database: UniProt
Entry: I3K9Y3_ORENI
LinkDB: I3K9Y3_ORENI
Original site: I3K9Y3_ORENI 
ID   I3K9Y3_ORENI            Unreviewed;       500 AA.
AC   I3K9Y3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   08-NOV-2023, entry version 67.
DE   SubName: Full=Endothelial lipase {ECO:0000313|Ensembl:ENSONIP00000017928.1};
GN   Name=LOC100710519 {ECO:0000313|Ensembl:ENSONIP00000017928.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017928.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000017928.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_003451122.1; XM_003451074.4.
DR   AlphaFoldDB; I3K9Y3; -.
DR   STRING; 8128.ENSONIP00000017928; -.
DR   ESTHER; oreni-i3k9y3; Lipoprotein_Lipase.
DR   Ensembl; ENSONIT00000017943.2; ENSONIP00000017928.1; ENSONIG00000014262.2.
DR   GeneID; 100710519; -.
DR   KEGG; onl:100710519; -.
DR   CTD; 9388; -.
DR   eggNOG; ENOG502QU8P; Eukaryota.
DR   GeneTree; ENSGT00940000159394; -.
DR   HOGENOM; CLU_027171_1_0_1; -.
DR   InParanoid; I3K9Y3; -.
DR   OMA; QMPVGHV; -.
DR   OrthoDB; 3428256at2759; -.
DR   TreeFam; TF324997; -.
DR   Proteomes; UP000005207; Linkage group LG12.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002330; Lipo_Lipase.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610:SF13; ENDOTHELIAL LIPASE; 1.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00822; LIPOLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..500
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003673706"
FT   DOMAIN          347..485
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   ACT_SITE        170
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        194
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        274
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         208
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         213
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ   SEQUENCE   500 AA;  56352 MW;  1F90EA557D1D1524 CRC64;
     MNHKSVLIRI FLLCAYPLFS SATEENAVLK GEDSGQNDLS TDSHSVGGII KYNMRKSLDL
     EQEGCYLKTG KNDCLEKCGF NATAKTIFII HGWTMSGMFE SWMHKLVSAL MQRESEANVV
     IVDWISRAQQ LYPDAVNHTY GVGLDIAELL NWLQDEHQLP LENVHLIGYS LGAHVAGYAG
     THVRGTIGRI TGLDPAGPMF EGVEKENRLS PDDADFVDVL HTYTREALGV SIGIQQPIGD
     IDIYPNGGDV QPGCGLGDVL AVAGNFMEVM KCEHERAVHL FVDSLMNKEH LSYAFQCTGP
     DRFKKGICLS CRKNRCNKIG YNATKMRKRR NSKMYLKTRA DTPFAGYHYQ MKMHVFNKKQ
     SDDADPIFNV KLYGEHKDTA DMFVDVHDNA ISLNMTNTFL VFTEEEIGEV LKIRLSWEGE
     SDSWSSMWKN IKKNFWGWNA NPSKPVLEVR RIRVKAGESQ KKYAFCAEDS SKTEISPGEY
     ITFVKCPDGW DAKPKKRVPM
//
DBGET integrated database retrieval system