ID   I3KA08_ORENI            Unreviewed;       678 AA.
AC   I3KA08;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Synaptotagmin like 5 {ECO:0000313|Ensembl:ENSONIP00000017953.2};
GN   Name=SYTL5 {ECO:0000313|Ensembl:ENSONIP00000017953.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017953.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000017953.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005457904.1; XM_005457847.2.
DR   AlphaFoldDB; I3KA08; -.
DR   Ensembl; ENSONIT00000017968.2; ENSONIP00000017953.2; ENSONIG00000014281.2.
DR   GeneID; 100696911; -.
DR   KEGG; onl:100696911; -.
DR   CTD; 94122; -.
DR   GeneTree; ENSGT00940000158618; -.
DR   InParanoid; I3KA08; -.
DR   OMA; PGTERRW; -.
DR   OrthoDB; 590187at2759; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd04029; C2A_SLP-4_5; 1.
DR   CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR037303; SLP-4/5_C2A.
DR   InterPro; IPR001565; Synaptotagmin.
DR   InterPro; IPR043567; SYTL1-5_C2B.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45716; BITESIZE, ISOFORM I; 1.
DR   PANTHER; PTHR45716:SF6; SYNAPTOTAGMIN-LIKE PROTEIN 5; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF02318; FYVE_2; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00399; SYNAPTOTAGMN.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50916; RABBD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          7..125
FT                   /note="RabBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50916"
FT   DOMAIN          352..474
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          510..642
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          151..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..52
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        192..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  76189 MW;  E789EF663A1FECFB CRC64;
     MEQSGKDLNL SFLLEHEREM ILKVLQKDEK LRKREEKRIR RLKNELLEVK QKGFIRPQDL
     GARQCTRCLK TLGLIFDRGD LCEECQSRIC SSCRVVNPRS RQWRCTFCDK LTELKVSSGE
     WFLEERSKRF ERGQLSSDVV KQTILSAPLS PEVKRAAPSK QEKPEPAVSN RLTVLNGARR
     KGGGAEGMES MASKDLRPRS LDRSSNLDAN RRVRPEGAES DDPEGAPEKK PSGPSISVSR
     PSVSSDHSRS ECDLLSPGSE PSDNALSVRS RSVPGLNETE FSDEEEDIDA LMSAHSRITG
     RRLSNAVSTS STPGSERRWG YLNVPDSDAE TSSINSTMSM YSETGDYGNA KVSGEILLNV
     SYSYKTGALS VLVKECHNLA VGDERRQRTD AYVKTYLLPD KSRQSKRKTS IKANTINPVF
     NETLRYVISH SQLETRTLQV SVWHHDRFGR NSFLGEVELA FDAWKFDCHI EEWYTLQPKV
     EGSIDSMLQY KGELTVVLKY IPEGKNVTPT ADQVQVKKSF LKGKKTSPLT LPEGGMVELL
     VKGAKNLTAV KSGGYSDPFV KGYLLPDSNK STKHKTVVER HTVNPQWNHT FTYCGLQPGD
     LNNVCLELTV WDKETVSSNV FLGGVRLGAG TGESYGKEVD WMDSYGEEKR LWQRMIENPE
     VPHECTLMLR SSMCKHNT
//