ID I3KA65_ORENI Unreviewed; 393 AA.
AC I3KA65;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=CD226 molecule {ECO:0000313|Ensembl:ENSONIP00000018010.2};
GN Name=cd226 {ECO:0000313|Ensembl:ENSONIP00000018010.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018010.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018010.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019218724.1; XM_019363179.1.
DR AlphaFoldDB; I3KA65; -.
DR STRING; 8128.ENSONIP00000018010; -.
DR Ensembl; ENSONIT00000018025.2; ENSONIP00000018010.2; ENSONIG00000014324.2.
DR eggNOG; ENOG502RY5X; Eukaryota.
DR GeneTree; ENSGT00500000044993; -.
DR HOGENOM; CLU_069157_0_0_1; -.
DR InParanoid; I3KA65; -.
DR OMA; QDIGVYH; -.
DR OrthoDB; 5354047at2759; -.
DR TreeFam; TF336260; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR042842; CD226.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR47011; CD226 ANTIGEN; 1.
DR PANTHER; PTHR47011:SF1; CD226 ANTIGEN; 1.
DR Pfam; PF07686; V-set; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..167
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 182..291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 393 AA; 44753 MW; 917CAE4BFC4F1423 CRC64;
MKCAPVAQVL LCSDRASRKC SLGASTRLIN AAFILPLWGK MEAVQKDCWY FVVLIFLPFL
KVAVQQRVPA TVRLEEGMVL HCLCPWDGSL SMVSWTKTSE KNPVAVFHPD FGVSFSLRFK
GRVEFLKSGP MDGSISIRNV THQDIGHYEC SVQTFPRGPW TRHIQVEDLD EPPEEDPTEP
APTQEAVSNE ELLVEQNSNL TIRCNYQQNG TVNQVILERM LHGQSWTIVG VCKKVEQGLV
AEDYSDRGRV SCEDSLDMSL HLTDVTQEDN GFYRCTFNTD VGQQNITMQL TIVASGWFSL
SLYMMYIYIG VGAAGLCLFI AIIIVVMRHR KRNKRTEYRV KLHPSQRQPN FYENIPMCPR
IKKSRQIRNC PVYANVQTVR SMKTTSQQRQ CNK
//
