ID I3KAA2_ORENI Unreviewed; 1605 AA.
AC I3KAA2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=CLTCL1 {ECO:0000313|Ensembl:ENSONIP00000018047.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018047.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018047.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8128.ENSONIP00000058722; -.
DR Ensembl; ENSONIT00000018062.2; ENSONIP00000018047.2; ENSONIG00000014354.2.
DR eggNOG; KOG0985; Eukaryota.
DR GeneTree; ENSGT00950000183166; -.
DR HOGENOM; CLU_002136_0_0_1; -.
DR TreeFam; TF300059; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF6; CLATHRIN HEAVY CHAIN 2; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 319..342
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1605 AA; 182998 MW; DCB2F84024F70FD6 CRC64;
PFLQNLGVNP ANIGFSYLTM ESDKFICIRE KVGEQNQVVI VDMSDPTNPI RRPISADSAI
MNPASKVIAL KAAKTLQIFN IEMKSKMKAH TMSEEVMFWK WISVNTVALV TDTAVYHWSM
EGDSQPTKVF DRHASLAGCQ IINYRTDEQQ KWLLLIGISA QQNRVVGAMQ LYSVDRKVSQ
PIEGHAAAFG EFKVEGNAKP STLFCFAVRS QAGGKLHIIE VGQPAAGNQP FAKKAVDVFF
PPEAQTDFPV AMQIGSKHGV IYLITKYGYI HLYDLESGVC IYMNRISAET IFVTAPHEAT
SGIIGVNKKG QVLSVCVEEE NIVNYATNVL QNPDLALRIA VRSNLAGAEE LFARKFNTLF
AQGSYSEAAK VAASAPKGIL RTAETIRKFQ SVPAQPGQAS PLLQYFGILL DQGQLNKFES
LELCRPVLQQ GRKQLLEKWL KEDKLECSEE LGDLVKASDP TLALSVYLRA NVPNKVIQCF
AETGQFQKIV LYAKKVGYTP DWVFLLRNVM RVNPDQGLQF AQMLVQDEEP LANINQIVDV
FMEGSLIQQC TSFLLDALKN NRPAEGHLQT RLLEMNLIHA PQVADAILGN QMFTHYDRAH
VAQLCEKAGL LQRALEHYTD LYDIKRAVVH THLLNPEWLV NFFGSLSVED SLECLRAMLS
ANIRQNLQLC VQVASKYHEQ LGTQALVELF ESFKSYEGLF YFLGSIVNFS QEPDVHFKYI
QAACKTGQIK EVERICRESN CYDPDRVKNF LKEAKLTDQL PLIIVCDRFD FVHDLVLYLY
RNSLQKYIEI YVQKVNPSRL PVVIGGLLDV DCSEDVIKNL IMVVRGQFST DELVDEVEKR
NRLKLLLPWL ESRIHEGCEE PATHNALAKI YIDSNNTPER FLKENPFYDS AVVGRYCEKR
DPHLACVAYE RGQCDLELIK VCNENSLFKS EARYLVRRKD PELWANVLEE NNPFRRQLID
QVVQTALSET QDPEEVSVTV KAFMTADLPN ELIELLEKIV LDNSVFSEHR NLQNLLILTA
IKADRTRVME YINRLDNYDA PDIANIAISN ELFEEAFAIF KKFDVNTSAI QVLIEHIGNL
DRAYEFAERC NEPAVWSQLA RAQLHRDLVK EAIDSYIKAV DPSAYMEVVN AASKNNNWED
LVKFLQMARK KARESYVETE LIFALAKTNR LAELEEFVSG PNNAHIQQVG DRCYEEGMYE
AAKLLYNNVS NFARLASTLV HLGEYQAAVD SARKANSTRT WKEVCFACVD GEEFRLAQIC
GLHIVIHADE LEDLISYYQD RGYFEELIAL LEAALGLERA HMGMFTELAI LYSKFKPQKM
REHLELFWSR VNIPKVLRAA EQSHLWAELV FLYDKYEEYD NAVITMMTHP TDAWKEGLFK
DIIAKVANVE LYYKALSFYL DYKPLLLNDL LTILSPRLDH SRAVIFFSKM NQLKLVKPYL
RSVQNHNNKS VNEALNNLLT EEEDYQGLRA SIDAYDNFDT IGLAQRLEKH ELIEFRRIAA
YLYKGNNRWR QSVELCKKDK LYKDAMLYAA ESKDAELAET LLQWFLEEGR KECFAACLFA
SYDLLHPDVV LELAWRHNIM DFAIAKHVNF HIDLKVYLPV LPADM
//
